Replaces Prod. #: BML-EI136
Potentiates the activity of protein kinase C (PKC) by inhibiting the diacylglycerol metabolism. Inhibits diacylglycerol kinase without affecting phosphodiesterase or phosphatidyl inositol kinase. It inhibits human platelet DAG kinase in intact cells (IC50=3.6μM) and in isolated membranes (IC50=6.7μM).
Product Details
| Alternative Name: | 6-[2-(4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl)ethyl]-7-methyl-5H-thiazolo-[3,2-a]pyrimidine-5-one |
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| Formula: | C27H26FN3OS |
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| MW: | 459.6 |
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| CAS: | 93076-89-2 |
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| Purity: | ≥99% |
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| Appearance: | Yellow powder. |
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| Solubility: | Soluble in DMSO, THF or DMF. Insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet: D. de Chaffoy de Courcelles, et al.; J. Biol. Chem.
260, 15762 (1985),
Abstract;
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