Nitric oxide (NO) donor. The half-life time of PAPA NONOate is 76.6 min. at 22°C in 0.1M phosphate buffer, pH 7.4. Decomposition of NONOates is nearly instantaneous at pH 5.0.
Product Details
| Alternative Name: | PAPA/NO, NOC-15, (Z)-1-[N-(3-Ammoniopropyl)-N-(n-propyl)amino]diazen-1-ium-1,2-diolate |
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| Formula: | C6H16N4O2 |
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| MW: | 176.2 |
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| CAS: | 146672-58-4 |
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| Purity: | ≥97% (TLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water or methanol. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Relatively stable in alkaline solution. |
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| Handling: | Protect from moisture. Keep under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Characterisation and comparison of temporal release profiles of nitric oxide generating donors: S.A. Bradley & J.R. Steinert; J. Neurosci. Methods
245, 116 (2015),
Application(s): Nitric Oxide Donor,
Abstract;
Dual effects of nitric oxide on the large conductance calcium-activated potassium channels of rat brain: J.E. Lee, et al.; J. Biochem. Mol. Biol.
39, 91 (2006),
Abstract;
Role of nitric oxide-induced mtDNA damage in mitochondrial dysfunction and apoptosis: L.I. Rachek, et al.; Free Radic. Biol. Med.
40, 754 (2006),
Abstract;
Nitric oxide donors alter cardiomyocyte cytokine secretion and cardiac function: D.L. Maass, et al.; Crit. Care Med.
33, 2794 (2005),
Abstract;
Nitric oxide inhibits cAMP-dependent CFTR trafficking in intestinal epithelial cells: A.C. Skinn & W.K. MacNaughton; Am. J. Physiol. Gastrointest. Liver Physiol.
289, G739 (2005),
Abstract;
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Position in cell cycle controls the sensitivity of colon cancer cells to nitric oxide-dependent programmed cell death: A. Jarry, et al.; Cancer Res.
64, 4227 (2004),
Abstract;
Effects of redox-related congeners of NO on apoptosis and caspase-3 activity: J. Haendeler, et al.; Nitric Oxide
1, 282 (1997),
Abstract;
New nitric oxide-releasing zwitterions derived from polyamines: J.A. Hrabie, et al.; J. Org. Chem. 58, 1472 (1993),
