Nitric oxide (NO) donor. The half-life time of MAHMA NONOate is 2.7 min. at 22°C in 0.1M phosphate buffer, pH 7.4. Decomposition of NONOates is nearly instantaneous at pH 5.0.
Product Details
| Alternative Name: | NOC-9, MAHMA/NO, (Z)-1-(N-Methyl-N-[6-(N-methylammoniohexyl)amino])-diazen-1-ium-1,2-diolate |
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| Formula: | C8H20N4O2 |
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| MW: | 204.3 |
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| CAS: | 146724-86-9 |
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| Purity: | ≥98% |
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| Appearance: | White to off-white crystalline solid. |
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| Solubility: | Soluble in water. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Relatively stable in alkaline solution. |
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| Handling: | Protect from light and moisture. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Modular Platform for the Development of Recombinant Hemoglobin Scavenger Biotherapeutics: R.M. Buzzi, et al.; Mol. Pharm.
18, 3158 (2021),
Abstract;
Nitric oxide donors inhibit 5-hydroxytryptamine (5-HT) uptake by the human 5-HT transporter (SERT): L.J. Bryan-Lluka, et al.; Br. J. Pharmacol.
143, 63 (2004),
Abstract;
Platelet inhibitory effects of the nitric oxide donor drug MAHMA NONOate in vivo in rats: K.L. Homer & J.C. Wanstall; Eur. J. Pharmacol.
482, 265 (2003),
Abstract;
Inhibition of rat platelet aggregation by the diazeniumdiolate nitric oxide donor MAHMA NONOate: K.L. Homer & J.C. Wanstall; Br. J. Pharmacol.
137, 1071 (2002),
Abstract;
New nitric oxide-releasing zwitterions derived from polyamines: J.A. Hrabie, et al.; J. Org. Chem. 58, 1472 (1993),
