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Nitric oxide donor
ALX-430-014-M005 5 mg 47.00 USD
ALX-430-014-M025 25 mg 152.00 USD
ALX-430-014-5005 5x5 mg 184.00 USD
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Nitric oxide (NO) donor. Induces apoptosis in macrophages. The half-life time of DETA NONOate is 20 hours at 37°C and 56 hours at 22-25°C in 0.1M phosphate buffer, pH 7.4. Decomposition of NONOates is nearly instantaneous at pH 5.0. DETA NONOate liberates 2 mol of NO per mol of parent compound.

Product Details

Alternative Name:NOC-18, DETA/NO, (Z)-1-[2-(2-Aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate, 3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene, 2,2'-(Hydroxynitrosohydrazino)bis-ethanamine
Purity:≥97% (1H-NMR)
Appearance:White to off-white solid.
Solubility:Soluble in water or ethanol.
Shipping:Dry Ice
Long Term Storage:-80°C
Handling:Protect from light and moisture.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Reduced expression of mitochondrial fumarate hydratase in progressive multiple sclerosis contributes to impaired in vitro mesenchymal stromal cell-mediated neuroprotection: P. Sarkar, et al.; Mult. Scler. 28, 1179 (2022), Abstract;
Nitric oxide attenuated transforming growth factor-β induced myofibroblast differentiation of human keratocytes: J.H. Park, et al.; Sci. Rep. 11, 41598 (2021), Abstract; Full Text
S-nitrosoglutathione inhibits adipogenesis in 3T3-L1 preadipocytes by S-nitrosation of CCAAT/enhancer-binding protein β: M. Mussbacher, et al.; Sci. Rep. 9, 15403 (2019), Abstract; Full Text
NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming: K.E. Hawkins, et al.; Cell Rep. 14, 1883 (2016), Application(s): Cell culture, Abstract;
The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes: P. Ge, et al.; Invest. Ophthalmol. Vis. Sci. 57, 1317 (2016), Application(s): Cell culture, Abstract; Full Text
Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid species, polysulfides, and nitroxyl: M.M. Cortese-Krott, et al.; PNAS 112, e4651 (2015), Application(s): Cell culture, Abstract; Full Text
Lipopolysaccharide induces inducible nitric oxide synthase-dependent podocyte dysfunction via a hypoxia-inducible factor 1-alpha and cell division control protein 42 and Ras-related C3 botulinum toxin substrate 1 pathway: A.K. Mashmoushi, et al.; Free Radic. Biol. Med. 84, 185 (2015), Application(s): Cell Culture, Assay, Abstract;
Novel Insights in mammalian catalase heme maturation: Effect of NO and Thioredoxin-1: R. Chakravarti, et al.; Free Radic. Biol. Med. 82, 105 (2015), Application(s): Cell Culture, Abstract;
Inflammatory cytokines induce MAdCAM-1 in murine hepatic endothelial cells and mediate alpha-4 beta-7 integrin dependent lymphocyte endothelial adhesion in vitro: T. Ando, et al.; BMC Physiol. 7, 10 (2007), Abstract; Full Text
The nitric oxide donor DETA-NONOate decreases matrix metalloproteinase-9 expression and activity in rat aortic smooth muscle and abdominal aortic explants: I. Sinha, et al.; Ann. Vasc. Surg. 20, 92 (2006), Abstract;
Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase: M. Palacios-Callender, et al.; PNAS 101, 7630 (2004), Abstract; Full Text
Hemodynamic effects of the nitric oxide donor DETA/NO in mice: C.G. Schyvens, et al.; Clin. Exp. Hypertens. 26, 525 (2004), Abstract;
The selective pulmonary vasodilatory effect of inhaled DETA/NO, a novel nitric oxide donor, in ARDS-a pilot human trial: C.F. Lam, et al.; J. Crit. Care 19, 48 (2004), Abstract;
In vitro cytotoxicity of glyco-S-nitrosothiols. a novel class of nitric oxide donors: H. Babich & H.L. Zuckerbraun; Toxicol. In Vitro 15, 181 (2001), Abstract;
Protective effect of thioredoxin upon NO-mediated cell injury in THP1 monocytic human cells: P.J. Ferret, et al.; Biochem. J. 346, 759 (2000), Abstract;
Expression and release of chemokines associated with apoptotic cell death in human promonocytic U937 cells and peripheral blood mononuclear cells: H. Muhl, et al.; Eur. J. Immunol. 29, 3225 (1999), Abstract;
In vitro cytotoxicity of the nitric oxide donor, S-nitroso-N-acetyl-penicillamine, towards cells from human oral tissue: H. Babich, et al.; Pharmacol. Toxicol. 84, 218 (1999), Abstract;
Resistance to nitric oxide-mediated apoptosis in HL-60 variant cells is associated with increased activities of Cu,Zn-superoxide dismutase and catalase: M. Yabuki, et al.; Free Radic. Biol. Med. 26, 325 (1999), Abstract;
Schedule and concentration-dependent induction of apoptosis in leukemia cells by nitric oxide: P.J. Shami, et al.; Leukemia 12, 1461 (1998), Abstract;
NOC, a nitric-oxide-releasing compound, induces dose dependent apoptosis in macrophages: M. Shimaoka, et al.; BBRC 209, 519 (1995), Abstract;
New nitric oxide-releasing zwitterions derived from polyamines: J.A. Hrabie, et al.; J. Org. Chem. 58, 1472 (1993),

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