Water soluble nitric oxide donor and potent inhibitor of ADP-induced platelet aggregation in platelet rich plasma (PRP). Stimulates cGMP production in platelets, granulocytes and polymorphonuclear leukocytes. Vasodepressant.
Product Details
| Alternative Name: | 1,2,3,4-Oxatriazolium, 5-amino-3-(3,4-dichlorophenyl)-, chloride |
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| Formula: | C7H4Cl2N4O . HCl |
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| MW: | 231.0 . 36.5 |
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| CAS: | 144575-47-3 |
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| Purity: | ≥97% (TLC) |
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| Identity: | Determined by NMR. |
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| Appearance: | White to off-white crystalline solid. |
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| Solubility: | Soluble in water, methanol or DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from oxygen. Use fresh solutions. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets: A. Fu, et al.; Cell Rep.
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Abstract;
Phospho-BAD BH3 Mimicry Protects β Cells and Restores Functional β Cell Mass in Diabetes: S. Ljubicic, et al; Cell Rep.
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Application(s): Cell Culture,
Abstract;
GEA3162, a nitric oxide-releasing agent, activates non-store-operated Ca2+ entry and inhibits store-operated Ca2+ entry pathways in neutrophils through thiol oxidation: M.F. Hsu, et al.; Eur. J. Pharmacol.
535, 43 (2006),
Abstract;
Flow cytometric evaluation of human neutrophil apoptosis during nitric oxide generation in vitro: the role of exogenous antioxidants: Z. Sulowska, et al.; Mediators Inflamm.
2005, 81 (2005),
Abstract;
Full Text
GEA 3162 decomposes to co-generate nitric oxide and superoxide and induces apoptosis in human neutrophils via a peroxynitrite-dependent mechanism: E.L. Taylor, et al.; Br. J. Pharmacol.
143, 179 (2004),
Abstract;
Ca(2+) entry activated by S-nitrosylation. Relationship to store-operated ca(2+) entry: H.T. Ma, et al.; J. Biol. Chem.
274, 35318 (1999),
Abstract;
Full Text
Mesoionic oxatriazole derivatives-a new group of NO-donors: G. Karup, et al.; Pol. J. Pharmacol.
46, 541 (1994),
Abstract;
Nitric oxide donor GEA 3162 inhibits endothelial cell-mediated oxidation of low density lipoprotein: U. Malo-Ranta, et al.; FEBS Lett.
337, 179 (1994),
Abstract;
Pharmacology of mesoionic oxatriazole derivatives in blood, cardiovascular and respiratory systems: T. Corell, et al.; Pol. J. Pharmacol.
46, 553 (1994),
Abstract;
Inhibition by nitric oxide-donors of human polymorphonuclear leucocyte functions: E. Moilanen, et al.; Br. J. Pharmacol.
109, 852 (1993),
Abstract;
Scavenging of superoxide anions by nitric oxide donors: J. Robak, et al.; Pharmacol. Res. 25 S2, 355 (1992),
