Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

GEA 3162

Nitric oxide donor
ALX-430-004-M010 10 mg 93.00 USD
Do you need bulk/larger quantities?
Water soluble nitric oxide donor and potent inhibitor of ADP-induced platelet aggregation in platelet rich plasma (PRP). Stimulates cGMP production in platelets, granulocytes and polymorphonuclear leukocytes. Vasodepressant.

Product Details

Alternative Name:1,2,3,4-Oxatriazolium, 5-amino-3-(3,4-dichlorophenyl)-, chloride
Formula:C7H4Cl2N4O . HCl
MW:231.0 . 36.5
Purity:≥97% (TLC)
Identity:Determined by NMR.
Appearance:White to off-white crystalline solid.
Solubility:Soluble in water, methanol or DMSO.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Protect from oxygen. Use fresh solutions.
Regulatory Status:RUO - Research Use Only
Please mouse over

Product Literature References

Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets: A. Fu, et al.; Cell Rep. 37, 110037 (2021), Abstract;
Phospho-BAD BH3 Mimicry Protects β Cells and Restores Functional β Cell Mass in Diabetes: S. Ljubicic, et al; Cell Rep. 10, 497 (2015), Application(s): Cell Culture, Abstract;
GEA3162, a nitric oxide-releasing agent, activates non-store-operated Ca2+ entry and inhibits store-operated Ca2+ entry pathways in neutrophils through thiol oxidation: M.F. Hsu, et al.; Eur. J. Pharmacol. 535, 43 (2006), Abstract;
Flow cytometric evaluation of human neutrophil apoptosis during nitric oxide generation in vitro: the role of exogenous antioxidants: Z. Sulowska, et al.; Mediators Inflamm. 2005, 81 (2005), Abstract; Full Text
GEA 3162 decomposes to co-generate nitric oxide and superoxide and induces apoptosis in human neutrophils via a peroxynitrite-dependent mechanism: E.L. Taylor, et al.; Br. J. Pharmacol. 143, 179 (2004), Abstract;
Ca(2+) entry activated by S-nitrosylation. Relationship to store-operated ca(2+) entry: H.T. Ma, et al.; J. Biol. Chem. 274, 35318 (1999), Abstract; Full Text
Mesoionic oxatriazole derivatives-a new group of NO-donors: G. Karup, et al.; Pol. J. Pharmacol. 46, 541 (1994), Abstract;
Nitric oxide donor GEA 3162 inhibits endothelial cell-mediated oxidation of low density lipoprotein: U. Malo-Ranta, et al.; FEBS Lett. 337, 179 (1994), Abstract;
Pharmacology of mesoionic oxatriazole derivatives in blood, cardiovascular and respiratory systems: T. Corell, et al.; Pol. J. Pharmacol. 46, 553 (1994), Abstract;
Inhibition by nitric oxide-donors of human polymorphonuclear leucocyte functions: E. Moilanen, et al.; Br. J. Pharmacol. 109, 852 (1993), Abstract;
Scavenging of superoxide anions by nitric oxide donors: J. Robak, et al.; Pharmacol. Res. 25 S2, 355 (1992),

Product Toolbox


Certificate of Analysis


By catalog section:


Technical Service
Customer Service