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Smoothened activator
ALX-420-045-M001 1 mg 67.00 USD
ALX-420-045-M005 5 mg 232.00 USD
ALX-420-045-M025 25 mg 765.00 USD
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Cell permeable purine compound. Induces osteoblast differentiation. Agonist of smoothened by activation of the Hedgehog (Hh) pathway. Also shown to induce transdifferentiation in pre-adipocytes and myoblasts. Binds to and activates 7-transmembrane receptor of Hh.

Product Details

Alternative Name:2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine
Purity:≥98% (HPLC)
Appearance:Off-white to beige solid.
Solubility:Soluble in DMSO (10mM).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Stock solutions are stable for up to 3 months when stored at -20°C.
Handling:Protect from light. After reconstitution, prepare aliquots and store at -20°C.
Regulatory Status:RUO - Research Use Only
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Product Literature References

A human stem cell-derived test system for agents modifying neuronal N-methyl-d-aspartate-type glutamate receptor Ca2+-signalling: S. Klima, et al.; Arch. Toxicol. 95, 1703 (2021), Abstract;
Millifluidic culture improves human midbrain organoid vitality and differentiation: E. Berger, et al.; Lab Chip 18, 3172 (2018), Abstract; Full Text
Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein: M. Ehrlich, et al.; Stem Cell Reports 5, 83 (2015), Application(s): Cell Culture, Abstract; Full Text
Lung Fibroblasts Share Mesenchymal Stem Cell Features Which Are Altered in Chronic Obstructive Pulmonary Disease via the Overactivation of the Hedgehog Signaling Pathway: F. Figeac, et al.; PLoS One 10, e0121579 (2015), Application(s): Cell Culture, Abstract; Full Text
Purmorphamine activates the Hedgehog pathway by targeting Smoothened: S. Sinha & J.K. Chen; Nat. Chem. Biol. 2, 29 (2006), Abstract;
Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells: M.M. Beloti, et al.; Cell Biol. Int. 29, 537 (2005), Abstract;
Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway: X. Wu, et al.; Chem. Biol. 11, 1229 (2004), Abstract;
A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells: X. Wu, et al.; JACS 124, 14520 (2002), Abstract;

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