Cell permeable purine compound. Induces osteoblast differentiation. Agonist of smoothened by activation of the Hedgehog (Hh) pathway. Also shown to induce transdifferentiation in pre-adipocytes and myoblasts. Binds to and activates 7-transmembrane receptor of Hh.
Product Details
| Alternative Name: | 2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine |
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| Formula: | C31H32N6O2 |
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| MW: | 520.6 |
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| CAS: | 483367-10-8 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Off-white to beige solid. |
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| Solubility: | Soluble in DMSO (10mM). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stock solutions are stable for up to 3 months when stored at -20°C. |
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| Handling: | Protect from light. After reconstitution, prepare aliquots and store at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A human stem cell-derived test system for agents modifying neuronal N-methyl-d-aspartate-type glutamate receptor Ca2+-signalling: S. Klima, et al.; Arch. Toxicol.
95, 1703 (2021),
Abstract;
Millifluidic culture improves human midbrain organoid vitality and differentiation: E. Berger, et al.; Lab Chip
18, 3172 (2018),
Abstract;
Full Text
Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein: M. Ehrlich, et al.; Stem Cell Reports
5, 83 (2015),
Application(s): Cell Culture,
Abstract;
Full Text
Lung Fibroblasts Share Mesenchymal Stem Cell Features Which Are Altered in Chronic Obstructive Pulmonary Disease via the Overactivation of the Hedgehog Signaling Pathway: F. Figeac, et al.; PLoS One
10, e0121579 (2015),
Application(s): Cell Culture,
Abstract;
Full Text
Purmorphamine activates the Hedgehog pathway by targeting Smoothened: S. Sinha & J.K. Chen; Nat. Chem. Biol.
2, 29 (2006),
Abstract;
Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells: M.M. Beloti, et al.; Cell Biol. Int.
29, 537 (2005),
Abstract;
Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway: X. Wu, et al.; Chem. Biol.
11, 1229 (2004),
Abstract;
A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells: X. Wu, et al.; JACS
124, 14520 (2002),
Abstract;
