Cooling agent. High-affinity TRPM8 (cold menthol receptor 1; CMR1) agonist. Has an EC50 value ~2'000 times lower than that of (-)-menthol (Prod. No. ALX-420-042).
Product Details
| Alternative Name: | (2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboximide |
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| Formula: | C18H27NO2 |
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| MW: | 289.4 |
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| CAS: | 68489-09-8 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by 1H-NMR and MS. |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in 100% ethanol, methanol, ethyl acetate, , dimethyl formamide or acetonitrile; insoluble in water or DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Characterisation of TRPM8 as a pharmacophore receptor: M. Bodding, et al.; Cell Calcium
42, 618 (2007),
Abstract;
Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators: B. Beck, et al.; Cell Calcium
41, 285 (2007),
Abstract;
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