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PPARδ agonist
ALX-420-032-M001 1 mg 95.00 USD
ALX-420-032-M005 5 mg 241.00 USD
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GW501516 is a specific agonist for PPARδ (EC50=1.1nM) with a 1'000-fold selectivity over the other human subtypes.

Product Details

Purity:≥98% (HPLC)
Identity:Identity determined by 1H-NMR and 13C-NMR.
Appearance:White to off-white solid.
Solubility:Soluble in DMSO (50mg/ml), dimethyl formamide (25mg/ml), 100% ethanol (12mg/ml) or methanol (50mg/ml); slightly soluble in water.
Shipping:Ambient Temperature
Long Term Storage:+4°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

PPARγ inhibits small airway remodeling through mediating the polarization homeostasis of alveolar macrophages in COPD: S. He, et al.; Clin. Immunol. 250, 109293 (2023), Abstract;
Acetyl-CoA-Carboxylase 1-mediated de novo fatty acid synthesis sustains Lgr5+ intestinal stem cell function: S. Li, et al.; Nat. Commun. 13, 3998 (2022), Abstract;
PPARδ Inhibits Hyperglycemia-Triggered Senescence of Retinal Pigment Epithelial Cells by Upregulating SIRT1: E.J. Lee, et al.; Antioxidants 11, 1207 (2022), Abstract;
Peroxisome proliferator-activated receptor δ rescues xCT-deficient cells from ferroptosis by targeting peroxisomes: J.S. Hwang, et al.; Biomed. Pharmacother. 143, 112223 (2021), Abstract;
Peroxisome proliferator-activated receptor-δ-mediated upregulation of catalase helps to reduce ultraviolet B-induced cellular injury in dermal fibroblasts: J. Hur, et al.; J. Dermatol. Sci. 923, 170 (2021), Abstract;
Cholesterol metabolism is a druggable axis that independently regulates tau and amyloid-β in iPSC-derived Alzheimer's disease neurons: R. van der Kant, et al.; Cell Stem Cell 24, 363 (2019), Abstract; Full Text
Increase in muscle endurance in mice by dietary Yamabushitake mushroom (Hericium erinaceus) possibly via activation of PPARδ: Y. Komiya, et al.; Anim. Sci. J. 90, 781 (2019), Abstract; Full Text
Ligand-activated PPARδ inhibits angiotensin II-stimulated hypertrophy of vascular smooth muscle cells by targeting ROS: E.S. Kang, et al.; PLoS One 14, e0210482 (2019), Abstract; Full Text
Ligand-Activated Peroxisome Proliferator-Activated Receptor δ Attenuates Vascular Oxidative Stress by Inhibiting Thrombospondin-1 Expression: M.Y. Ahn, et al.; J. Vasc. Res. 55, 75 (2018), Abstract;
CRY1/2 Selectively Repress PPARd and Limit Exercise Capacity: S.D. Jordan, et al.; Cell Metab. 26, 243 (2017), Abstract; Full Text
Ligand-activated PPARδ upregulates α-smooth muscle actin expression in human dermal fibroblasts: a potential role for PPARδ in wound healing: S.A. Ham, et al.; J. Dermatol. Sci. 80, 186 (2015), Application(s): Cell Culture, Abstract;
PPARβ/δ ameliorates fructose-induced insulin resistance in adipocytes by preventing Nrf2 activation: E. Barroso, et al.; Biochim. Biophys. Acta 1852, 1049 (2015), Application(s): Cell Culture, Abstract;
PPARδ modulates oxLDL-induced apoptosis of vascular smooth muscle cells through a TGF-β/FAK signaling axis: J.S. Hwang, et al.; Int. J. Biochem. Cell. Biol. 62, 54 (2015), Application(s): Cell Culture, Abstract;
Activation of peroxisome proliferator-activated receptor-{delta} by GW501516 prevents fatty acid-induced nuclear factor-{kappa}B activation and insulin resistance in skeletal muscle cells: T. Coll, et al.; Endocrinology 151, 1560 (2010), Abstract;
Activation of PPARdelta promotes mitochondrial energy metabolism and decreases basal insulin secretion in palmitate-treated beta-cells: L. Jiang, et al.; Mol. Cell. Biol. 343, 249 (2010), Abstract;
Cross-talk between vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling in melanoma cells: P. Sertznig, et al.; Anticancer Res. 29, 3647 (2009), Abstract;
Effects of the PPAR-beta agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination: A. Defaux, et al.; J. Neuroinflammation 6, 15 (2009), Abstract;
Determination of the critical amino acids involved in the peroxisome proliferator-activated receptor (PPAR) delta selectivity of phenylpropanoic acid-derived agonists: J. Kasuga, et al.; Chem. Med. Chem. 3, 1662 (2008), Abstract;
A short and efficient synthesis of the pharmacological research tool GW501516 for the peroxisome proliferator-activated receptor delta: Z.L. Wei & A.P. Kozikowski; J. Org. Chem. 68, 9116 (2003), Abstract;
Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)-synthesis and biological activity: M.L. Sznaidman, et al.; Bioorg. Med. Chem. Lett. 13, 1517 (2003), Abstract;
Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism: A.J. Gilde, et al.; Circ. Res. 92, 518 (2003), Abstract;
Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity: Y.X. Wang, et al.; Cell 113, 159 (2003), Abstract;
PPARdelta activation induces COX-2 gene expression and cell proliferation in human hepatocellular carcinoma cells: B. Glinghammar, et al.; BBRC 308, 361 (2003), Abstract;
The peroxisome proliferator-activated receptor beta/delta agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells: U. Dressel, et al.; Mol. Endocrinol. 17, 2477 (2003), Abstract;
A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport: W.R. Oliver, Jr., et al.; PNAS 98, 5306 (2001), Abstract; Full Text

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