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Inducer of intracellular ROS generation
ALX-420-027-M005 5 mg 111.00 USD
ALX-420-027-M010 10 mg 169.00 USD
ALX-420-027-M025 25 mg 370.00 USD
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Redox-cycling agent that induces intracellular superoxide anion formation and, depending on the concentration, induces cell proliferation, apoptosis or necrosis. DMNQ does not react with free thiol groups, is non-alkylating and adduct-forming in contrast to other quinones. Thus, DMNQ is a valuable tool for the generation of reactive oxygen species (ROS) in order to study the role of ROS in cell toxicity, apoptosis and necrosis.

Product Details

Alternative Name:2,3-Dimethoxy-1,4-naphthoquinone
Purity:≥99% (TLC)
Identity:Determined by NMR.
Appearance:Yellow crystalline solid.
Solubility:Soluble in acetone, DMSO or methanol.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Iron deficiency aggravates DMNQ-induced cytotoxicity via redox cycling in kidney-derived cells: D. Yoshihara, et al.; Free Radic. Res. 56, 544 (2022), Abstract;
A CRISPR screen identifies a pathway required for paraquat-induced cell death: C.R. Reczek, et al.; Nat. Chem. Biol. 13, 1274 (2017), Abstract; Full Text
The Bioenergetic Health Index is a Sensitive Measure of Oxidative Stress in Human Monocytes: B.K. Chacko, et al. ; Redox Biol. 8, 43 (2015), Application(s): Inhibited mitochondrial function in human monocytes, Abstract;
Oxidative stress promotes polarization of human T cell differentiation toward a T helper 2 phenotype: M.R. King, et al.; J. Immunol. 176, 2765 (2006), Abstract; Full Text
Potentiation of nitric oxide synthase expression by superoxide in interleukin 1 beta-stimulated rat mesangial cells: K.F. Beck, et al.; FEBS Lett. 435, 35 (1998), Abstract;
The relative importance of oxidative stress versus arylation in the mechanism of quinone-induced cytotoxicity to platelets: S.A. Seung, et al.; Chem. Biol. Interact. 113, 133 (1998), Abstract;
DNA single-strand breakage in mammalian cells induced by redox cycling quinones in the absence of oxidative stress: W.A. Morgan; J. Biochem. Toxicol. 10, 227 (1995), Abstract;
Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells: J.M. Dypbukt, et al.; J. Biol. Chem. 269, 30553 (1994), Abstract; Full Text

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