Moderately potent indolactam activator of protein kinase C (PKC). Increases cytoplasmic mRNAs. Exhibits tumor promoting activity. Directs differentiation of human embryonic stem cells to pancreatic progenitor cells.
Product Details
| Formula: | C17H23N3O2 |
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| MW: | 301.4 |
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| CAS: | 90365-57-4 |
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| RTECS: | UY8547000 |
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| Purity: | ≥95% (1H-NMR) |
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| Identity: | May contain traces of (+)-Indolactam V. |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO or 100% ethanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Differential protein kinase C ligand regulation detected in vivo by a phenotypic yeast assay: H.L. Shieh, et al.; Mol. Carcinogen.
12, 166 (1995),
Abstract;
Interleukin-4 signals regulating CD23 gene expression in human B cells: protein kinase C-independent signaling pathways: C.E. Lee, et al.; Cell Immunol.
146, 171 (1993),
Abstract;
(-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells: J. Heikkilä & K. Akerman; BBRC
162, 1207 (1989),
Abstract;
Structure-activity studies on synthetic analogues (indolactams) of the tumor promoter teleocidin: H. Fujiki, et al.; Gann
75, 866 (1984),
Abstract;
