Replaces Prod. #: BML-CN253
NO donor which spontaneously releases NO under physiological conditions. Half-life of 159 hours under physiological conditions. Selectively inhibits platelet activation and displays cardioprotective effects. Inhibits NF-κB activation. Inhibits endothelial cell proliferation and induces apoptosis in T cells.
Product Details
Alternative Name: | S-Nitroso-L-glutathione, N-(N-L-γ-Glutamyl-S-nitroso-L-cysteinyl)-glycine |
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Formula: | C10H16N4O7S |
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MW: | 336.3 |
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CAS: | 57564-91-7 |
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Purity: | ≥98% (HPLC) |
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Appearance: | Crystalline solid. |
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Solubility: | Soluble in water (25mg/ml), DMSO (20mg/ml) or PBS; sparingly soluble in 100% ethanol, methanol or dimethyl formamide. |
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Shipping: | Ambient Temperature |
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Long Term Storage: | -20°C |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
S-nitrosoglutathione inhibits adipogenesis in 3T3-L1 preadipocytes by S-nitrosation of CCAAT/enhancer-binding protein β: M. Mussbacher, et al.; Sci. Rep.
9, 15403 (2019),
Abstract;
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S-nitrosoglutathione promotes cell wall remodelling, alters the transcriptional profile and induces root hair formation in the hairless root hair defective 6 (rhd6) mutant of Arabidopsis thaliana: C.F. Moro, et al.; New Phytol.
213, 1771 (2017),
Abstract;
Chronic p38 mitogen-activated protein kinase inhibition improves vascular function and remodeling in angiotensin II-dependent hypertension: S.A. Potthoff, et al.; J. Renin Angriotensin Aldosterone Syst.
17, 1470320316653284 (2016),
Application(s): Assessing vasorelaxation in isolated perfused mouse kidney; renal vasodilator responses,
Abstract;
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ROS-Mediated Inhibition of S-nitrosoglutathione Reductase Contributes to the Activation of Anti-oxidative Mechanisms: I. Kovacs, et al.; Front Plant Sci.
7, 1 (2016),
Abstract;
Full Text
Identification of nuclear target proteins for S-nitrosylation in pathogen-treated Arabidopsis thaliana cell cultures: M. Chaki, et al.; Plant Sci.
238, 115 (2015),
Application(s): Cell Culture,
Abstract;
GSNO attenuates EAE disease by S-nitrosylation-mediated modulation of endothelial-monocyte interactions: R. Prasad, et al.; Glia
55, 65 (2007),
Abstract;
Mechanisms of cystic fibrosis transmembrane conductance regulator activation by S-nitrosoglutathione: L. Chen, et al.; J. Biol. Chem.
281, 9190 (2006),
Abstract;
Modulation of glucose uptake in adipose tissue by nitric oxide-generating compounds: D. McGrowder, et al.; J. Biosci.
31, 347 (2006),
Abstract;
Nitric oxide induces SOCS-1 expression in human monocytes in a TNF-alpha-dependent manner: M. C. Gonzalez-Leon, et al.; J. Endotoxin Res.
12, 296 (2006),
Abstract;
Association of the ERK1/2 and p38 kinase pathways with nitric oxide-induced apoptosis and cell cycle arrest in colon cancer cells: H. K. Jeon, et al.; Cell. Biol. Toxicol.
21, 115 (2005),
Abstract;
Protection from experimental asthma by an endogenous bronchodilator: G. Que, et al.; Science
308, 1618 (2005),
Abstract;
Redox regulation of PTEN by S-nitrosothiols: C.X. Yu, et al.; Mol. Pharmacol.
68, 847 (2005),
Abstract;
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S-Nitrosoglutathione reduces inflammation and protects brain against focal cerebral ischemia in a rat model of experimental stroke: M. Khan, et. al.; J. Cereb. Blood Flow Metab.
25, 177 (2005),
Abstract;
Endothelial heme oxygenase-1 induction by hypoxia. Modulation by inducible nitric-oxide synthase and S-nitrosothiols: R. Motterlini, et al.; J. Biol. Chem.
275, 13613 (2000),
Abstract;
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The dual role of S-nitrosoglutathione (GSNO) during thymocyte apoptosis: K. Sandau & B. Brune; Cell Signal.
8, 173 (1996),
Abstract;
Induction and stabilization of I kappa B alpha by nitric oxide mediates inhibition of NF-kappa B: H.B. Peng, et al.; J. Biol. Chem.
270, 14214 (1995),
Abstract;
Nitric oxide inhibition of endothelial cell mitogenesis and proliferation: R. Sarkar, et al.; Surgery
118, 274 (1995),
Abstract;
Nitric oxide inhibits macrophage-colony stimulating factor gene transcription in vascular endothelial cells: H.B. Peng, et al.; J. Biol. Chem.
270, 17050 (1995),
Abstract;
S-nitrosoglutathione improves functional recovery in the isolated rat heart after cardioplegic ischemic arrest-evidence for a cardioprotective effect of nitric oxide: E.A. Konorev, et al.; J. Pharmacol. Exp. Ther.
274, 200 (1995),
Abstract;
Effects of S-nitroso-glutathione in the human forearm circulation: evidence for selective inhibition of platelet activation: A.J. de Belder, et al.; Cardiovasc. Res.
28, 691 (1994),
Abstract;
Biological activity of S-nitrosothiols: the role of nitric oxide: W.R. Mathews & S.W. Kerr; J. Pharmacol. Exp. Ther.
267, 1529 (1993),
Abstract;
An investigation of some S-nitrosothiols, and of hydroxy-arginine, on the mouse anococcygeus: A. Gibson, et al.; Br. J. Pharmacol.
107, 715 (1992),
Abstract;
S-nitroso-glutathione inhibits platelet activation in vitro and in vivo: M.W. Radomski, et al.; Br. J. Pharmacol.
107, 745 (1992),
Abstract;