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Nitric oxide donor
ALX-420-002-M025 25 mg 122.00 USD
ALX-420-002-M100 100 mg 372.00 USD
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Replaces Prod. #: BML-CN253

NO donor which spontaneously releases NO under physiological conditions. Half-life of 159 hours under physiological conditions. Selectively inhibits platelet activation and displays cardioprotective effects. Inhibits NF-κB activation. Inhibits endothelial cell proliferation and induces apoptosis in T cells.

Product Details

Alternative Name:S-Nitroso-L-glutathione, N-(N-L-γ-Glutamyl-S-nitroso-L-cysteinyl)-glycine
Purity:≥98% (HPLC)
Appearance:Crystalline solid.
Solubility:Soluble in water (25mg/ml),  DMSO (20mg/ml) or PBS; sparingly soluble in 100% ethanol, methanol or dimethyl formamide.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

S-nitrosoglutathione inhibits adipogenesis in 3T3-L1 preadipocytes by S-nitrosation of CCAAT/enhancer-binding protein β: M. Mussbacher, et al.; Sci. Rep. 9, 15403 (2019), Abstract; Full Text
S-nitrosoglutathione promotes cell wall remodelling, alters the transcriptional profile and induces root hair formation in the hairless root hair defective 6 (rhd6) mutant of Arabidopsis thaliana: C.F. Moro, et al.; New Phytol. 213, 1771 (2017), Abstract;
Chronic p38 mitogen-activated protein kinase inhibition improves vascular function and remodeling in angiotensin II-dependent hypertension: S.A. Potthoff, et al.; J. Renin Angriotensin Aldosterone Syst. 17, 1470320316653284 (2016), Application(s): Assessing vasorelaxation in isolated perfused mouse kidney; renal vasodilator responses, Abstract; Full Text
ROS-Mediated Inhibition of S-nitrosoglutathione Reductase Contributes to the Activation of Anti-oxidative Mechanisms: I. Kovacs, et al.; Front Plant Sci. 7, 1 (2016), Abstract; Full Text
Identification of nuclear target proteins for S-nitrosylation in pathogen-treated Arabidopsis thaliana cell cultures: M. Chaki, et al.; Plant Sci. 238, 115 (2015), Application(s): Cell Culture, Abstract;
GSNO attenuates EAE disease by S-nitrosylation-mediated modulation of endothelial-monocyte interactions: R. Prasad, et al.; Glia 55, 65 (2007), Abstract;
Mechanisms of cystic fibrosis transmembrane conductance regulator activation by S-nitrosoglutathione: L. Chen, et al.; J. Biol. Chem. 281, 9190 (2006), Abstract;
Modulation of glucose uptake in adipose tissue by nitric oxide-generating compounds: D. McGrowder, et al.; J. Biosci. 31, 347 (2006), Abstract;
Nitric oxide induces SOCS-1 expression in human monocytes in a TNF-alpha-dependent manner: M. C. Gonzalez-Leon, et al.; J. Endotoxin Res. 12, 296 (2006), Abstract;
Association of the ERK1/2 and p38 kinase pathways with nitric oxide-induced apoptosis and cell cycle arrest in colon cancer cells: H. K. Jeon, et al.; Cell. Biol. Toxicol. 21, 115 (2005), Abstract;
Protection from experimental asthma by an endogenous bronchodilator: G. Que, et al.; Science 308, 1618 (2005), Abstract;
Redox regulation of PTEN by S-nitrosothiols: C.X. Yu, et al.; Mol. Pharmacol. 68, 847 (2005), Abstract; Full Text
S-Nitrosoglutathione reduces inflammation and protects brain against focal cerebral ischemia in a rat model of experimental stroke: M. Khan, et. al.; J. Cereb. Blood Flow Metab. 25, 177 (2005), Abstract;
Endothelial heme oxygenase-1 induction by hypoxia. Modulation by inducible nitric-oxide synthase and S-nitrosothiols: R. Motterlini, et al.; J. Biol. Chem. 275, 13613 (2000), Abstract; Full Text
The dual role of S-nitrosoglutathione (GSNO) during thymocyte apoptosis: K. Sandau & B. Brune; Cell Signal. 8, 173 (1996), Abstract;
Induction and stabilization of I kappa B alpha by nitric oxide mediates inhibition of NF-kappa B: H.B. Peng, et al.; J. Biol. Chem. 270, 14214 (1995), Abstract;
Nitric oxide inhibition of endothelial cell mitogenesis and proliferation: R. Sarkar, et al.; Surgery 118, 274 (1995), Abstract;
Nitric oxide inhibits macrophage-colony stimulating factor gene transcription in vascular endothelial cells: H.B. Peng, et al.; J. Biol. Chem. 270, 17050 (1995), Abstract;
S-nitrosoglutathione improves functional recovery in the isolated rat heart after cardioplegic ischemic arrest-evidence for a cardioprotective effect of nitric oxide: E.A. Konorev, et al.; J. Pharmacol. Exp. Ther. 274, 200 (1995), Abstract;
Effects of S-nitroso-glutathione in the human forearm circulation: evidence for selective inhibition of platelet activation: A.J. de Belder, et al.; Cardiovasc. Res. 28, 691 (1994), Abstract;
Biological activity of S-nitrosothiols: the role of nitric oxide: W.R. Mathews & S.W. Kerr; J. Pharmacol. Exp. Ther. 267, 1529 (1993), Abstract;
An investigation of some S-nitrosothiols, and of hydroxy-arginine, on the mouse anococcygeus: A. Gibson, et al.; Br. J. Pharmacol. 107, 715 (1992), Abstract;
S-nitroso-glutathione inhibits platelet activation in vitro and in vivo: M.W. Radomski, et al.; Br. J. Pharmacol. 107, 745 (1992), Abstract;

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