Alkylates DNA, forming DNA-DNA cross-links that result in inhibition of DNA synthesis and cell death. Interestingly the repair enzyme O6-alkylguanine-DNA alkyltransferase, long thought to be involved with resistance to methylating and chloroethylating agents, may also contribute to resistance to the cytotoxic and mutagenic effects of cyclophosphamide.
Product Details
Alternative Name: | 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide, Cytoxan |
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Formula: | C7H15CI2N2O2P . H2O |
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MW: | 261.1 . 18.0 |
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Source: | Synthetic. |
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CAS: | 6055-19-2 |
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MI: | 14: 2747 |
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RTECS: | RP6157750 |
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Purity: | ≥97% (HPLC) |
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Identity: | Determined by IR and UV. |
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Appearance: | White to off-white crystalline solid. |
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Solubility: | Soluble in water; slightly soluble in 100% ethanol. |
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Shipping: | Ambient Temperature |
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Long Term Storage: | -20°C |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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