Alkylates DNA, forming DNA-DNA cross-links that result in inhibition of DNA synthesis and cell death. Interestingly the repair enzyme O6-alkylguanine-DNA alkyltransferase, long thought to be involved with resistance to methylating and chloroethylating agents, may also contribute to resistance to the cytotoxic and mutagenic effects of cyclophosphamide.
Product Specification
| Alternative Name: | 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide, Cytoxan |
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| Formula: | C7H15CI2N2O2P . H2O |
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| MW: | 261.1 . 18.0 |
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| Source: | Synthetic. |
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| CAS: | 6055-19-2 |
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| MI: | 14: 2747 |
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| RTECS: | RP6157750 |
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| Purity: | ≥97% (HPLC) |
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| Identity: | Determined by IR and UV. |
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| Appearance: | White to off-white crystalline solid. |
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| Solubility: | Soluble in water; slightly soluble in 100% ethanol. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Protective effect of curcumin and chlorophyllin against DNA mutation induced by cyclophosphamide or benzo[a]pyrene: M.A. Ibrahim, et al.; Z. Naturforsch.
62, 215 (2007),
Abstract;
Ginsenoside Rh(2) enhances antitumour activity and decreases genotoxic effect of cyclophosphamide: Z. Wang, et al.; Basic Clin. Pharmacol. Toxicol.
98, 411 (2006),
Abstract;
Mechanisms of resistance to the toxicity of cyclophosphamide: M.P. Gamcsik, et al.; Curr. Pharm. Des.
5, 587 (1999),
Abstract;
An overview of cyclophosphamide and ifosfamide pharmacology: R.A. Fleming; Pharmacotherapy
17, 146S (1997),
Abstract;
Induction of apoptosis in murine tumors by cyclophosphamide: R.E. Meyn, et al.; Cancer Chemother. Pharmacol.
33, 410 (1994),
Abstract;
