Antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting topoisomerase II. Induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Has been shown to be an inhibitor of DNA methylation.
Product Details
| Alternative Name: | 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione . dihydrochloride |
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| Formula: | C22H28N4O6 . 2HCl |
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| MW: | 444.5 . 73.0 |
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| Source: | Synthetic. |
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| CAS: | 70476-82-3 |
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| MI: | 14: 6217 |
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| RTECS: | CB5748500 |
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| Purity: | ≥97% (Assay) |
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| Identity: | Determined by IR. |
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| Appearance: | Blue to black crystalline solid. |
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| Solubility: | Soluble in water; slightly soluble in 100% ethanol or methanol; insoluble in acetonitrile or acetone. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Direct modification of the 5-HT3 receptor current by some anticancer drugs: Y. Nakamura, et al.; Eur. J. Pharmacol.
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Abstract;
Increased Systemic Exposure of Methotrexate by a Polyphenol-Rich Herb via Modulation on Efflux Transporters Multidrug Resistance-Associated Protein 2 and Breast Cancer Resistance Protein: C.P. Yu, et al.; J. Pharm. Sci.
105, 343 (2016),
Application(s): Used as a probe substrate for evaluating the activity of BCRP,
Abstract;
A molecular understanding of mitoxantrone-DNA adduct formation: effect of cytosine methylation and flanking sequences: B.S. Parker, et al.; J. Biol. Chem.
279, 18814 (2004),
Abstract;
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A comparison of the in vitro genotoxicity of anticancer drugs idarubicin and mitoxantrone: J. Blasiak, et al.; Acta Biochim. Pol.
49, 145 (2002),
Abstract;
Full Text
Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cells: A. Skladanowski & J. Konopa; Br. J. Cancer
82, 1300 (2000),
Abstract;
Mitoxantrone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the chemotherapy of cancer: D. Faulds, et al.; Drugs
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