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Mitoxantrone . dihydrochloride

DNA intercalator and Topoisomerase II inhibitor
ALX-400-050-M010 10 mg 45.00 USD
ALX-400-050-M050 50 mg 79.00 USD
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Antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting topoisomerase II. Induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Has been shown to be an inhibitor of DNA methylation.

Product Details

Alternative Name:1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione . dihydrochloride
Formula:C22H28N4O6 . 2HCl
MW:444.5 . 73.0
MI:14: 6217
Purity:≥97% (Assay)
Identity:Determined by IR.
Appearance:Blue to black crystalline solid.
Solubility:Soluble in water; slightly soluble in 100% ethanol or methanol; insoluble in acetonitrile or acetone.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

Inhibitory Effect of Mitoxantrone on Collagen Synthesis in Dermal Fibroblasts: K. Kim, et al.; Ann. Dermatol. 34, 206 (2022), Abstract;
Direct modification of the 5-HT3 receptor current by some anticancer drugs: Y. Nakamura, et al.; Eur. J. Pharmacol. 821, 21 (2017), Abstract;
Increased Systemic Exposure of Methotrexate by a Polyphenol-Rich Herb via Modulation on Efflux Transporters Multidrug Resistance-Associated Protein 2 and Breast Cancer Resistance Protein: C.P. Yu, et al.; J. Pharm. Sci. 105, 343 (2016), Application(s): Used as a probe substrate for evaluating the activity of BCRP, Abstract;
A molecular understanding of mitoxantrone-DNA adduct formation: effect of cytosine methylation and flanking sequences: B.S. Parker, et al.; J. Biol. Chem. 279, 18814 (2004), Abstract; Full Text
A comparison of the in vitro genotoxicity of anticancer drugs idarubicin and mitoxantrone: J. Blasiak, et al.; Acta Biochim. Pol. 49, 145 (2002), Abstract; Full Text
Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cells: A. Skladanowski & J. Konopa; Br. J. Cancer 82, 1300 (2000), Abstract;
Mitoxantrone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the chemotherapy of cancer: D. Faulds, et al.; Drugs 41, 400 (1991), Abstract;