Potent inhibitor of alkaline phosphatase and tyrosine phosphates. Regarding decavanadate: across the pH range of 1-13, simple aqueous solutions of [VO4]3- ion involve a dozen or more ionic species, both monomeric and oligomeric, whose abundances depend strongly on pH and [VO4]3- concentration. At pH 3.75 a stable complex can be prepared (see below in Fohr et al.) which contains ten vanadium atoms and hence is a decavanadate ion. When diluted to pH 7.2, the decavanadate species has a half-life time of about 2 hours. Fohr et al., also provide directions for generating control solutions of mixed vanadate complexes in which decavanadate is absent and monomeric orthovanadate is present. Decavanadate inhibits inositol 1,4,5-trisphosphate- (IP3) induced calcium release from permeabilized endocrine cells and the binding of [3H]IP3 to its receptor in cerebellar and adrenal cortical membranes.
Product Details
Alternative Name: | Sodium vanadate |
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Formula: | Na3VO4 |
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MW: | 183.9 |
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CAS: | 13721-39-6 |
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RTECS: | YW1120000 |
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Purity: | ≥90% (dry basis titration) |
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Appearance: | White to off-white. |
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Solubility: | Soluble in water (100mg/ml). |
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Shipping: | Ambient Temperature |
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Long Term Storage: | Ambient |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Abstract;
Full Text
Is decavanadate a specific inositol 1,4,5-trisphosphate receptor antagonist? [letter]: J. Strupish, et al.; Biochem. J.
277, 294 (1991),
Abstract;
Characterization of the inositol 1,4,5-trisphosphate-induced calcium release from permeabilized endocrine cells and its inhibition by decavanadate and p-hydroxymercuribenzoate: K.J. Fohr, et al.; Biochem. J.
262, 83 (1989),
Abstract;
Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate: G. Swarup, et al.; BBRC
107, 1104 (1982),
Abstract;
Inhibition of human alkaline phosphatases by vanadate: L.E. Seargeant & R.A. Stinson; Biochem. J.
181, 247 (1979),
Abstract;
3rd Edition of interscience (New York): F.A. Cotton & G. Wilkinson; Adv. Inorg. Chem. 3, 820 (1972),