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Sodium orthovanadate

Alkaline phosphatase inhibitor
ALX-400-032-G005 5 g 47.00 USD
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Potent inhibitor of alkaline phosphatase and tyrosine phosphates. Regarding decavanadate: across the pH range of 1-13, simple aqueous solutions of [VO4]3- ion involve a dozen or more ionic species, both monomeric and oligomeric, whose abundances depend strongly on pH and [VO4]3- concentration. At pH 3.75 a stable complex can be prepared (see below in Fohr et al.) which contains ten vanadium atoms and hence is a decavanadate ion. When diluted to pH 7.2, the decavanadate species has a half-life time of about 2 hours. Fohr et al., also provide directions for generating control solutions of mixed vanadate complexes in which decavanadate is absent and monomeric orthovanadate is present. Decavanadate inhibits inositol 1,4,5-trisphosphate- (IP3) induced calcium release from permeabilized endocrine cells and the binding of [3H]IP3 to its receptor in cerebellar and adrenal cortical membranes.

Product Details

Alternative Name:Sodium vanadate
Purity:≥90% (dry basis titration)
Appearance:White to off-white.
Solubility:Soluble in water (100mg/ml).
Shipping:Ambient Temperature
Long Term Storage:Ambient
Regulatory Status:RUO - Research Use Only

Product Literature References

Bacillus anthracis lethal toxin negatively modulates ILC3 function through perturbation of IL-23-mediated MAPK signaling: S. Seshadri, et al.; PLoS Pathog. 13, e1006690 (2017), Abstract; Full Text
Is decavanadate a specific inositol 1,4,5-trisphosphate receptor antagonist? [letter]: J. Strupish, et al.; Biochem. J. 277, 294 (1991), Abstract;
Characterization of the inositol 1,4,5-trisphosphate-induced calcium release from permeabilized endocrine cells and its inhibition by decavanadate and p-hydroxymercuribenzoate: K.J. Fohr, et al.; Biochem. J. 262, 83 (1989), Abstract;
Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate: G. Swarup, et al.; BBRC 107, 1104 (1982), Abstract;
Inhibition of human alkaline phosphatases by vanadate: L.E. Seargeant & R.A. Stinson; Biochem. J. 181, 247 (1979), Abstract;
3rd Edition of interscience (New York): F.A. Cotton & G. Wilkinson; Adv. Inorg. Chem. 3, 820 (1972),

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PTP Inhibitor
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