Modulates thiol groups in biological systems, especially in those involving cAMP, Ca2+ and inositol phosphate. Causes a release of calcium from intracellular stores in many cells types. Has toxic effects on several cell types. Induces apoptosis in vitro.
Product Specification
| Alternative Name: | Ethyl mercurithiosalicylic acid . Na, Mercurothiolate |
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| Formula: | C9H9HgO2SNa |
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| MW: | 404.8 |
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| CAS: | 54-64-8 |
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| MI: | 14: 9317 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in water (600mg/ml) or methanol. |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Handling: | Protect from light. |
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Product Literature References
Being on the track of thimerosal: A. Madi; Acta Microbiol. Immunol. Hung.
52, 95 (2005),
Abstract;
Thimerosal stimulates Ca2+ flux through inositol 1,4,5-trisphosphate receptor type 1, but not type 3, via modulation of an isoform-specific Ca2+-dependent intramolecular interaction: G. Bultynck, et al.; Biochem. J.
381, 87 (2004),
Abstract;
Thimerosal induces DNA breaks, caspase-3 activation, membrane damage, and cell death in cultured human neurons and fibroblasts: D. S. Baskin, et al.; Toxicol. Sci.
74, 361 (2003),
Abstract;
Thimerosal: a versatile sulfhydryl reagent, calcium mobilizer, and cell function-modulating agent:: J.G. Elferink; Gen. Pharmacol.
33, 1 (1999), (Review),
Abstract;
The effects of thimerosal on calcium uptake and inositol 1,4,5- trisphosphate-induced calcium release in cerebellar microsomes: L.G. Sayers, et al.; Biochem. J.
289, 883 (1993),
Abstract;
Antibody to the inositol trisphosphate receptor blocks thimerosal- enhanced Ca(2+)-induced Ca2+ release and Ca2+ oscillations in hamster eggs: S. Miyazaki, et al.; FEBS Lett.
309, 180 (1992),
Abstract;
Thimerosal causes calcium oscillations and sensitizes calcium-induced calcium release in unfertilized hamster eggs: K. Swann; FEBS Lett.
278, 175 (1991),
Abstract;
Disulfide linkage of biotin identifies a 106-kDa Ca2+ release channel in sarcoplasmic reticulum: N.F. Zaidi, et al.; J. Biol. Chem.
264, 21737 (1989),
Abstract;
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