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Pyrrolidinedithiocarbamic acid . ammonium salt

Inhibitor of NF-κB activation
ALX-400-002-G005 5 g 45.00 USD
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Inhibitor of NF-κB activation (induced by either PMA or TNF-α) in various cell types.

Product Details

Alternative Name:Ammoniumpyrrolidinedithiocarbamate, Ammoniumtetramethylenedithiocarbamate
Formula:C5H8NS2 . NH4
MW:146.3 . 18.0
Purity:≥98% (HPLC)
Appearance:White to-off white solid.
Solubility:Soluble in water.
Shipping:Ambient Temperature
Long Term Storage:+4°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation: S. Hamarsheh, et al.; Nat. Commun. 11 , 1659 (2020), Abstract; Full Text
Visfatin Promotes Monocyte Adhesion by Upregulating ICAM-1 and VCAM-1 Expression in Endothelial Cells via Activation of p38-PI3K-Akt Signaling and Subsequent ROS Production and IKK/NF-κB Activation: Y.T. Lin, et al.; Cell. Physiol. Biochem. 52, 1398 (2019), Abstract; Full Text
Interaction with macrophages attenuates Equine Fibroblast-Like Synoviocyte ADAMTS5 (aggrecanase-2) gene expression following inflammatory stimulation: R.E. Morgan, et al.; J. Orthop. Res. 36, 2178 (2018), Abstract;
Pyrrolidine dithiocarbamate inhibits TNF-alpha-dependent activation of NF-kappaB by increasing intracellular copper level in human aortic smooth muscle cells: A. Iseki, et al.; Biochem. Biophys. Res. Commun. 276, 88 (2000), Abstract;
Dual activity of pyrrolidine dithiocarbamate on kappaB-dependent gene expression in U937 cells: I. Regulation by the phorbol ester TPA: K. Watanabe, et al.; Cell Signal. 11, 479 (1999), Abstract;
Dual activity of pyrrolidine dithiocarbamate on kappaB-dependent gene expression in U937 cells: II. Regulation by tumour necrosis factor-alpha: K. Watanabe, et al.; Cell Signal. 11, 371 (1999), Abstract;
Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate prevents In vivo expression of proinflammatory genes: S.F. Liu, et al.; Circulation 100, 1330 (1999), Abstract;
Zinc is required in pyrrolidine dithiocarbamate inhibition of NF-kappaB activation: C.H. Kim, et al.; FEBS Lett. 449, 28 (1999), Abstract;
In vivo inhibition of nuclear factor-kappa B activation prevents inducible nitric oxide synthase expression and systemic hypotension in a rat model of septic shock: S.F. Liu, et al.; J. Immunol. 159, 3976 (1997), Abstract;
In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation: T.S. Blackwell, et al.; Immunol. 157, 1630 (1996), Abstract;
Pyrrolidine dithiocarbamate differentially affects interleukin 1 beta- and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells: W. Eberhardt, et al.; BBRC 200, 163 (1994), Abstract;
Pyrrolidine dithiocarbamate inhibits induction of nitric oxide synthase activity in rat alveolar macrophages: M.P. Sherman, et al.; BBRC 191, 1301 (1993), Abstract;
Pyrrolidine dithiocarbamate inhibits NF-kappa B mobilization and TNF production in human monocytes: H.W. Ziegler-Heitbrock, et al.; J. Immunol. 151, 6986 (1993), Abstract;
Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells: R. Schreck, et al.; J. Exp. Med. 175, 1181 (1992), Abstract;

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