Flavonoid glycoside. Reduces venous hyperpressure. Reduces capillary hyperpermeability and the expression of endothelial adhesion molecules (ICAM1, VCAM1). Effectively inhibits the P-glycoprotein (Pgp)-mediated efflux in cells. Anti-inflammatory.
Product Details
| Alternative Name: | 3’,5,7-Trihydroxy-4’-methoxyflavone 7-rutinoside |
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| Formula: | C28H32O15 |
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| MW: | 608.5 |
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| Source: | Isolated from Citrus aurantium L. and Citrus reticulate Blanca. |
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| CAS: | 520-27-4 |
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| MI: | 14: 3297 |
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| Purity: | ≥90% (HPLC) |
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| Identity: | Determined by IR. |
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| Appearance: | Light yellow to brown yellow powder. |
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| Solubility: | Soluble in DMSO (50mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Treatment of metastatic melanoma B16F10 by the flavonoids tangeretin, rutin, and diosmin: C. Martinez Conesa, et al.; J. Agric. Food Chem.
53, 6791 (2005),
Abstract;
The effect of diosmin hesperidin on intestinal ischaemia--reperfusion injury: M. Pehlivan, et al.; Acta Chir. Belg.
104, 715 (2004),
Abstract;
Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells: Q. Zheng, et al.; J. Cancer Res. Clin. Oncol.
128, 539 (2002),
Abstract;
Anti-inflammatory activity of diosmin and hesperidin in rat colitis induced by TNBS: M.E. Crespo, et al.; Planta Med.
65, 651 (1999),
Abstract;
Inhibition of lipopolysaccharide (LPS)-induced endothelial cytotoxicity by diosmin: M.F. Melzig & R. Loose; Pharmazie
54, 298 (1999),
Abstract;
Diosmin and diosmetin are agonists of the aryl hydrocarbon receptor that differentially affect cytochrome P450 1A1 activity: H.P. Ciolino, et al.; Cancer Res.
58, 2754 (1998),
Abstract;
Full Text
Modulation by phytochemicals of cytochrome P450-linked enzyme activity: R.W. Teel & H. Huynh; Cancer Lett.
133, 135 (1998),
Abstract;
Chemopreventive effects of diosmin and hesperidin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary-bladder carcinogenesis in male ICR mice: M. Yang, et al.; Int. J. Cancer
73, 719 (1997),
Abstract;
Venous elasticity after treatment with Daflon 500 mg: V. Ibegbuna, et al.; Angiology
48, 45 (1997),
Abstract;
Diosmin-induced increase in sensitivity to Ca2+ of the smooth muscle contractile apparatus in the rat isolated femoral vein: J.P. Savineau & R. Marthan; Br. J. Pharmacol.
111, 978 (1994),
Abstract;
Full Text
Antioxidant activity of micronized diosmin on oxygen species from stimulated human neutrophils: B. Cypriani, et al.; Biochem. Pharmacol.
45, 1531 (1993),
Abstract;
Amine uptake inhibition by diosmin and diosmetin in human neuronal and neuroendocrine cell lines: E. Sher, et al.; Pharmacol. Res.
26, 395 (1992),
Abstract;
Clinical trial of oral diosmin (Daflon) in the treatment of hemorrhoids: W. Thanapongsathorn & T. Vajrabukka; Dis. Colon Rectum
35, 1085 (1992),
Abstract;
