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Nobiletin

Anti-inflammatory and antioxidant



ALX-385-026-M010	10 mg	639.00 USD
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Antioxidant and anti-inflammatory. Inhibits the phosphorylation of mitogen-activated protein kinase MEK. Suppresses the expression of matrix metalloproteinases (MMP) 1, 3 and 9, that are involved in the breakdown of the extracellular matrix during tumor metastasis. Suppresses NF-κB transcriptional activation, nitric oxide (NO) and PGE₂ production, inducible nitric oxide synthase (iNOS; NOS II) and cyclooxygenase-2 (COX-2) expression.

Product Details

Alternative Name:	3’,4’,5,6,7,8-Hexamethoxyflavone, 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one, CCRIS 9012, NSC 76751

Formula:	C₂₁H₂₂O₈

MW:	402.4

CAS:	478-01-3

Purity:	≥95% (HPLC)

Appearance:	White to off-white powder.

Solubility:	Soluble in methanol; sparingly soluble in water or ether.

Shipping:	Ambient Temperature

Long Term Storage:	-20°C

Regulatory Status:	RUO - Research Use Only

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Product Literature References

A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells: Y. Miyata, et al.; BBRC 366, 168 (2008), Abstract;

Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus: K. Matsuzaki, et al.; Eur. J. Pharmacol. 578, 194 (2008), Abstract;

Nobiletin enhances differentiation and lipolysis of 3T3-L1 adipocytes: T. Saito, et al.; BBRC 357, 371 (2007), Abstract;

Nobiletin from citrus fruit peel inhibits the DNA-binding activity of NF-kappaB and ROS production in LPS-activated RAW 264.7 cells: S.Y. Choi, et al.; J. Ethnopharmacol. 113, 149 (2007), Abstract;

Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice: A. Nakajima, et al.; J. Pharmacol. Sci. 105, 122 (2007), Abstract; Full Text

Protective effects of citrus nobiletin and auraptene in transgenic rats developing adenocarcinoma of the prostate (TRAP) and human prostate carcinoma cells: M. Tang, et al.; Cancer Sci. 98, 471 (2007), Abstract;

Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells: K.L. Morley, et al.; Cancer Lett. 251, 168 (2007), Abstract;

Inhibition of cell proliferation by nobiletin, a dietary phytochemical, associated with apoptosis and characteristic gene expression, but lack of effect on early rat hepatocarcinogenesis in vivo: H. Ohnishi, et al.; Cancer Sci. 95, 936 (2004), Abstract; Full Text

Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages: N. Lin, et al.; Biochem. Pharmacol. 65, 2065 (2003), Abstract;

The citrus flavonoid, nobiletin, inhibits peritoneal dissemination of human gastric carcinoma in SCID mice: A. Minagawa, et al.; Jpn. J. Cancer Res. 92, 1322 (2001), Abstract;