Antioxidant flavonoid. Has antitumor and chemopreventive properties. Anti-inflammatory. Inhibits NF-κB activation.
PIM1 kinase inhibitor IC50=0.78µM.
Product Details
Alternative Name: | 3,3',4',5,5',7-Hexahydroxyflavone |
|
Formula: | C15H10O8 |
|
MW: | 318.2 |
|
CAS: | 529-44-2 |
|
MI: | 14: 6332 |
|
RTECS: | LK8646000 |
|
Purity: | ≥90% (HPLC) |
|
Appearance: | Light yellow-green crystals. |
|
Solubility: | Soluble in alcohol; slightly soluble in water (warm); insoluble in acetic acid. |
|
Shipping: | Ambient |
|
Long Term Storage: | -20°C |
|
Handling: | Protect from light. |
|
Regulatory Status: | RUO - Research Use Only |
|
Please mouse over
Product Literature References
A comparison of resveratrol and other polyphenolic compounds on Notch activation and endothelial cell activity: B. LaFoya, et al.; PLoS One
14, e0210607 (2019),
Abstract;
Full Text
Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase: S. Holder, et al.; Mol. Cancer Ther.
6, 163 (2007),
Abstract;
Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1: K.W. Lee, et al.; Carcinogenesis
28, 1918 (2007),
Abstract;
Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity: J. Lu, et al.; Cancer Res.
66, 4410 (2006),
Abstract;
Mitochondrial-dependent, reactive oxygen species-independent apoptosis by myricetin: roles of protein kinase C, cytochrome c, and caspase cascade: C.H. Ko, et al.; Biochem. Pharmacol.
69, 913 (2005),
Abstract;
Myricetin inhibits matrix metalloproteinase 2 protein expression and enzyme activity in colorectal carcinoma cells: C.H. Ko, et al.; Mol. Cancer Ther.
4, 281 (2005),
Abstract;
In vitro cytotoxicity of glyco-S-nitrosothiols. a novel class of nitric oxide donors: H. Babich & H.L. Zuckerbraun; Toxicol. In Vitro
15, 181 (2001),
Abstract;
Suppression of TNFalpha-mediated NFkappaB activity by myricetin and other flavonoids through downregulating the activity of IKK in ECV304 cells: S. H. Tsai, et al.; J. Cell Biochem.
74, 606 (1999),
Abstract;
Biological effects of myricetin: K. C. Ong & H. E. Khoo; Gen. Pharmacol.
29, 121 (1997), (Review),
Abstract;
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radic. Biol. Med.
20, 933 (1996), (Review),
Abstract;