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HIF-1α inhibitor
ALX-385-009-G001 1 g 39.00 USD
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Antioxidant flavonoid. Shows anti-inflammatory and antitumor properties. Inhibits hypoxia-inducible factor-1α (HIF-1α). Induces apoptosis.

Product Details

Alternative Name:5,7-Dihydroxyflavone
MI:14: 2256
Purity:≥96% (UHPLC)
Appearance:Yellow to tan solid.
Solubility:Soluble in pyridine or alkaline solutions; insoluble in water.
Long Term Storage:Ambient
Regulatory Status:RUO - Research Use Only
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Product Literature References

Enzymatic synthesis of α-flavone glucoside via regioselective transglucosylation by amylosucrase from Deinococcus geothermalis: S.W. Jang, et al.; PLoS One 13, e0207466 (2018), Abstract;
Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis: B. Fu, et al.; Mol. Cancer Ther. 6, 220 (2007), Abstract;
Dietary flavonoids: effects on xenobiotic and carcinogen metabolism:: Y.J. Moon, et al.; Toxicol. In Vitro 20, 187 (2006), (Review), Abstract;
Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21Waf1/Cip1 expression: involvement of p38 mitogen-activated protein kinase: M.S. Weng, et al.; Biochem. Pharmacol. 69, 1815 (2005), Abstract;
Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells: K.J. Woo, et al.; Biochem. Biophys. Res. Commun. 325, 1215 (2004), Abstract;
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radic. Biol. Med. 20, 933 (1996), (Review), Abstract;

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