Antioxidant flavonoid. Shows anti-inflammatory and antitumor properties. Inhibits hypoxia-inducible factor-1α (HIF-1α). Induces apoptosis.
Product Details
| Alternative Name: | 5,7-Dihydroxyflavone |
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| Formula: | C15H10O4 |
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| MW: | 254.2 |
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| CAS: | 480-40-0 |
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| MI: | 14: 2256 |
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| RTECS: | LK8329050 |
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| Purity: | ≥96% (UHPLC) |
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| Appearance: | Yellow to tan solid. |
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| Solubility: | Soluble in pyridine or alkaline solutions; insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Enzymatic synthesis of α-flavone glucoside via regioselective transglucosylation by amylosucrase from Deinococcus geothermalis: S.W. Jang, et al.; PLoS One
13, e0207466 (2018),
Abstract;
Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis: B. Fu, et al.; Mol. Cancer Ther.
6, 220 (2007),
Abstract;
Dietary flavonoids: effects on xenobiotic and carcinogen metabolism:: Y.J. Moon, et al.; Toxicol. In Vitro
20, 187 (2006), (Review),
Abstract;
Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21Waf1/Cip1 expression: involvement of p38 mitogen-activated protein kinase: M.S. Weng, et al.; Biochem. Pharmacol.
69, 1815 (2005),
Abstract;
Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells: K.J. Woo, et al.; Biochem. Biophys. Res. Commun.
325, 1215 (2004),
Abstract;
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radic. Biol. Med.
20, 933 (1996), (Review),
Abstract;
