18-membered macrolide. Active against trichomonads and various RNA and DNA viruses. Weakly active against some fungi. Has antitrypanosomal activity.
Product Specification
| Alternative Name: | 23-O-De(4-O-aminocarbonyl-2,6-dideoxy-β-D-arabino-hexopyranosyl)-23-O-[4-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-1,4-dioxo-2-butenyl]concanamycin A |
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| Formula: | C48H71NO14 |
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| MW: | 886.1 |
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| Source: | Isolated from Streptomyces sp. AM-2604. |
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| CAS: | 84777-85-5 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in acetone, chloroform, 100% ethanol or methanol; insoluble in water or hexane. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Technical Info/Product Notes: | Manufactured with courtesy strain from The Kitasato Institute. |
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Product Literature References
Selective and potent in vitro antitrypanosomal activities of ten microbial metabolites: K. Otoguro, et al.; J. Antibiot.
61, 372 (2008),
Abstract;
The mode of action of a novel 18-membered macrolide, virustomycin A (AM-2604 A), on Trichomonas foetus: S. Omura, et al. ; J. Antibiot.
36, 1755 (1983),
Abstract;
Full Text
The structure of virustomycin A: S. Omura, et al.; J. Antibiot.
36, 1783 (1983),
Abstract;
AM-2604 A, a new antiviral antibiotic produced by a strain of Streptomyces: S. Omura, et al.; J. Antibiot.
35, 1632 (1982),
Abstract;
Full Text
