Nerve growth factor (NGF) potentiator. Has been shown to enhance the neurite outgrowth in the presence of NGF in the rat pheochromocytoma cell line PC12.
Product Details
| Alternative Name: | Orbuticin derivative, (3R,7S,11R,17R,21R)-7-(Hydroxymethyl)-3,11,17,21-tetramethyl-13,14:23,24-bis[1,3]butadieno-25,27,29,31-tetrahydroxy-2,6,10,16,20-pentaoxacyclotetracosa-13,23-diene-1,5,9,15,19-pentone |
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| Formula: | C32H38O15 |
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| MW: | 662.7 |
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| Source: | Isolated from Penicillium sp. FKI-5387. |
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| CAS: | 141731-76-2 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | Pale white solid. |
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| Solubility: | Soluble in 100% ethanol, acetone, acetonitrile, chloroform, ethyl acetate or methanol; insoluble in water or hexane. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Scientific Background: | NG 012, together with NG 011, was first isolated from a culture broth of Penicillium verruculosum F-4542. |
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| Technical Info/Product Notes: | Manufactured with courtesy strain from The Kitasato Institute. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Antifungal macrocyclic polylactones from Penicillium verruculosum: J. Breinholt, et al.; J. Antibiot.
46, 1101 (1993),
Abstract;
NG-011 and NG-012, novel potentiators of nerve growth factor. I. Taxonomy, isolation, and physico-chemical and biological properties: M. Ito, et al.; J. Antibiot.
45, 1559 (1992),
Abstract;
NG-011 and NG-012, novel potentiators of nerve growth factor. II. The structure determination of NG-011 and NG-012: M. Ito, et al.; J. Antibiot.
45, 1556 (1992),
Abstract;
