Macrolide antibiotic. Inhibitor of cell-cell adhesion molecule. Inhibits the growth of some ascomycetes, basidiomycetes, oomycetes and gram-positive bacteria, including the medically important Staphylococcus aureus (IC50 of ≤500 μg/ml in agar based tests). Ineffective against yeasts and gram-negative bacteria when tested at concentrations up to 700 μg/ml.
Product Details
| Alternative Name: | (4S,7E,13E)-4α,10α,16α-Trimethyl-9β,15β-dihydroxy-1,5,11-trioxa-7,13-cyclohexadecadiene-2,6,12-trione |
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| Formula: | C16H22O8 |
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| MW: | 342.4 |
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| Source: | Isolated from Paraconiothyrium sporulosum strain FO-5050. |
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| CAS: | 172923-77-2 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in ethyl acetate, chloroform, dimethyl ether, DMSO or methanol; insoluble in water or hexane. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Macrosphelide A was originally isolated from Microsphaeropsis sp.FO-5050 and Coniothyrium minitans. C. minitans is a mycoparasite of sclerotia of Sclerotinia sclerotiorum and Sclerotium cepivorum. Manufactured with courtesy strain from The Kitasato Institute. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Antimicrobial activity of Coniothyrium minitans and its macrolide antibiotic macrosphelide A.: N. Tomprefa, et al.; J. Appl. Microbiol.
106, 2048 (2009),
Abstract;
Production of macrosphelide A by the mycoparasite Coniothyrium minitans.: M.P. McQuilken, et al.; FEMS Microbiol. Lett.
219, 27 (2003),
Abstract;
Macrosphelide, a novel inhibitor of cell-cell adhesion molecule. II. Physiochemical properties and structural elucidation.: S. Takamatsu, et al.; J. Antibiot.
49, 35 (1996),
Abstract;
Macrosphelide, a novel inhibitor of cell-cell adhesion molecule. I. Taxonomy, fermentation, isolation and biological activities.: M. Hayashi, et al.; J. Antibiot.
48, 1435 (1995),
Abstract;
