Atpenin-related, specific inhibitor of complex II (succinate-ubiquinone oxidoreductase). Less potent than atpenins. Has antifungal, antibacterial and herbicidal activity. Inhibits the NADH-fumarate reductase activity of adult Ascaris suum mitochondria.
Product Details
| Alternative Name: | 2-Hydroxy-5,6-dimethoxy-3-[(2R)-2-methylhex-4-enoyl]-1H-pyridin-4-one |
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| Formula: | C14H19NO5 |
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| MW: | 281.3 |
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| Source: | Isolated from Trichoderma harzianum FKI-1509. |
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| CAS: | 137813-88-8 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in ethyl acetate or methanol; insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Technical Info/Product Notes: | Manufactured with courtesy strain from The Kitasato Institute. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Factors affecting the production of Trichoderma harzianum secondary metabolites during the interaction with different plant pathogens: F. Vinale, et al.; Lett. Appl. Microbiol.
48, 705 (2009),
Abstract;
Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase): H. Miyadera, et al.; PNAS
100, 473 (2003),
Abstract;
Biological Activity of (-)-Harzianopyridone isolated from Trichoderma harzianum: H.G. Cutler & J.M. Jacyno; Agric. Biol. Chem.
55, 2629 (1991),
Abstract;
Full Text
Structure and biosynthesis of harzianopyridone, an antifungal metabolite of Trichoderma harzianum: J.M. Dickinson, et al.; J. Chem. Soc. 1885 (1989),
Abstract;
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