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Hygromycin B (sterile-filtered solution in PBS)

Protein synthesis inhibitor
ALX-380-306-G001 1 g 138.00 USD
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Antibiotic. Inhibits growth of prokaryotic and eukaryotic microorganisms and mammalian cells. Inhibits protein synthesis at the translocation step on the 70S ribosome and causes misreading of the mRNA. Penetrates cells that have been permeabilized by virus infection, hence it can act as an effective antiviral agent.

Product Details

Alternative Name:O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-O-β-D-talopyranosyl(1-5)-2-deoxy-N3-methyl-D-streptamine
Source:Isolated from Streptomyces hygroscopicus.
MI:14: 4852
Purity:≥90% (HPLC)
Purity Detail:Sterile filtered.
Appearance:Liquid. In PBS.
Shipping:Ambient Temperature - Dangerous Good
Long Term Storage:+4°C
Use/Stability:Working hygromycin solutions (≤2mg/ml) are stable for up to 1 month when stored at +4°C.
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress: M.H. Lehner, et al.; Cell Rep. 41, 111536 (2022), Abstract;
GSK3B induces autophagy by phosphorylating ULK1: H.Y. Ryu, et al.; Exp. Mol. Med. 53, 369 (2021), Abstract;
Clr-a: A Novel Immune-Related C-Type Lectin-like Molecule Exclusively Expressed by Mouse Gut Epithelium: E. Rutkowski, et al.; J. Immunol. 198, 916 (2017), Abstract;
Hygromycin B inhibition of protein synthesis and ribosome biogenesis in Escherichia coli: S. M. McGaha & W. S. Champney; Antimicrob. Agents Chemother. 51, 591 (2007), Abstract;
A ribosomal ATPase is a target for hygromycin B inhibition on Escherichia coli ribosomes: M. C. Ganoza & M. C. Kiel; Antimicrob. Agents Chemother. 45, 2813 (2001), Abstract;
The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit:: D.E. Brodersen, et al.; Cell 103, 1143 (2000), Abstract;
Induction of p53-independent apoptosis by hygromycin B: suppression by Bcl-2 and adenovirus E1B 19-kDa protein: G. Chen, et al.; Exp. Cell Res. 221, 55 (1995), Abstract;
Antiviral effects of hygromycin B, a translation inhibitor nonpermeant to uninfected cells: J. C. Lacal & L. Carrasco; Antimicrob. Agents Chemother. 24, 273 (1983), Abstract;
The Isolation of a Second Antibiotic from Streptomyces hygroscopicus: R. L. Mann & W. W. Bromer; J. Am. Chem. Soc. 80, 2714 (1958),

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