Inhibits expression of inducible nitric oxide synthase (iNOS; NOSII). Has antifungal and antibiotic activity. Inhibits cell division. Similar to Curvulin.
Product Details
| Alternative Name: | 4,5,6,7,8,9-Hexahydro-11,13-dihydroxy-4-methyl-2H-3-benzoxacyclododecin-2,10(1H)-dione |
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| Formula: | C16H20O5 |
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| MW: | 292.3 |
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| CAS: | 10140-70-2 |
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| MI: | 14: 2676 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White to off-white crystalline solid. |
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| Solubility: | Soluble in methanol, dioxane or pyridine; insoluble in water, benzene or hexane. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Inhibitors of inducible NO synthase expression: total synthesis of (S)-curvularin and its ring homologues: S. Elzner, et al.; ChemMedChem
3, 924 (2008),
Abstract;
Birch reduction and its application in the total synthesis of natural products: G.S.R. Subba Rao; Pure Appl. Chem. 75, 1443 (2003),
Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi: Y. Yao, et al.; Mol. Pharmacol.
63, 383 (2003),
Abstract;
Full Text
Cytotoxic activity of macrocyclic metabolites from fungi: K. Horakova & V. Betina; Neoplasma
24, 21 (1977),
Abstract;
Curvularin from penicillium baradicum Baghdadi NRRL 3754, and biological effects: R.F. Vesonder, et al.; J. Environ. Sci. Health B.
11, 289 (1976),
Abstract;
