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Tosufloxacin . tosylate

Fluoroquinolone antibacterial agent
ALX-380-303-M250 250 mg 142.00 USD
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Fluoroquinolone antibacterial agent. Inhibits bacterial DNA gyrase (topoisomerase). Effective against Gram-positive and Gram-negative aerobic bacteria, anaerobic bacteria and Chlamydia trachomatis.

Product Details

Alternative Name:7-(3-Amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid . tosylate, A-64730
Formula:C19H15F3N4O3 . C7H8O3S
MW:404.4 . 172.2
MI:14: 9555
Purity:≥98% (HPLC)
Appearance:White to yellow crystalline solid.
Solubility:Slightly soluble in water.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

Tosufloxacin tosilate-induced thrombocytopenic purpura: H. Takahama & H. Tazaki; J. Dermatol. 34, 465 (2007), Abstract;
Clinical assessment of tosufloxacin tosilate: S. Kohno; J. Infect. Chemother. 8, 19 (2002), (Review), Abstract;
Antibacterial activities of tosufloxacin against anaerobic bacteria and the electron micrograph of its bactericidal effects: M. Takahata & T. Nishino; Chemotherapy 43, 153 (1997), Abstract;
Stereoselective analysis of the disposition of tosufloxacin enantiomers in man: R. Minami, et al.; Eur. J. Clin. Pharmacol. 45, 489 (1993), Abstract;
In-vitro activity of tosufloxacin, a new quinolone antibacterial agent: M.A. Cooper, et al.; J. Antimicrob. Chemother. 29, 639 (1992), Abstract;
The in-vitro activity of tosufloxacin, a new fluorinated quinolone, compared with that of ciprofloxacin and temafloxacin: A. King, et al.; J. Antimicrob. Chemother. 28, 719 (1991), Abstract;
In vitro activity of tosufloxacin, a new quinolone, against respiratory pathogens derived from cystic fibrosis sputum: A.G. Arguedas, et al.; Antimicrob. Agents Chemother. 34, 2223 (1990), Abstract; Full Text
Synthesis and biological properties of A-71497: a prodrug of tosufloxacin: D.T. Chu, et al.; Drugs Exp. Clin. Res. 16, 435 (1990), Abstract;

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By target:
DNA gyrase
By biological activity:
DNA gyrase Inhibitor
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