Fluoroquinolone with broad spectrum activity against Gram-negative and Gram-positive bacteria. Inhibits bacterial DNA-gyrase and topoisomerase IV. May cause dysglycemia. Stimulates short-term self-renewal in both human and mouse embryonic stem cells.
Product Details
| Alternative Name: | AM-1155, 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid |
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| Formula: | C19H22FN3O4 |
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| MW: | 375.4 |
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| CAS: | 112811-59-3 |
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| MI: | 14: 4376 |
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| Purity: | ≥98% (Assay) |
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| Appearance: | White to yellow crystalline powder. |
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| Solubility: | Soluble in water at pH 2-5 (40-60mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Gatifloxacin produces both hypoglycemia and hyperglycemia: a retrospective study: H. Haerian, et al.; Am. J. Med. Sci.
335, 95 (2008),
Abstract;
Gatifloxacin affects GLUT1 gene expression and disturbs glucose homeostasis in vitro: T.F. Ge, et al.; Eur. J. Pharmacol.
573, 70 (2007),
Abstract;
Gatifloxacin-associated hypoglycemia: T. Ali, et al.; J. Okla. State Med. Assoc.
100, 425 (2007),
Abstract;
Contributions of the 8-methoxy group of gatifloxacin to resistance selectivity, target preference, and antibacterial activity against Streptococcus pneumoniae: H. Fukuda, et al.; Antimicrob. Agents Chemother.
45, 1649 (2001),
Abstract;
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Gatifloxacin: C.M. Perry, et al.; Drugs
58, 683 (1999), (Review),
Abstract;
Primary targets of fluoroquinolones in Streptococcus pneumoniae: H. Fukuda & K. Hiramatsu; Antimicrob. Agents Chemother.
43, 410 (1999),
Abstract;
Full Text
Activities of gatifloxacin compared to those of seven other agents against anaerobic organisms: L.M. Ednie, et al.; Antimicrob. Agents Chemother.
42, 2459 (1998),
Abstract;
Full Text
Inhibitory activities of gatifloxacin (AM-1155), a newly developed fluoroquinolone, against bacterial and mammalian type II topoisomerases: M. Takei, et al.; Antimicrob. Agents Chemother.
42, 2678 (1998),
Abstract;
Full Text
Comparison of the antibacterial activities of the quinolones Bay 12-8039, gatifloxacin (AM 1155), trovafloxacin, clinafloxacin, levofloxacin and ciprofloxacin: A. Bauernfeind; J. Antimicrob. Chemother.
40, 639 (1997),
Abstract;
Full Text
