Fluoroquinolone antibacterial agent. Inhibits bacterial DNA gyrase (topoisomerase). Inhibits cell division and causes double-strand breaks in the bacterial chromosome. Broad-spectrum antibiotic effective against Gram-positive, Gram-negative and anaerobic bacteria. Effective against Mycobacterium tuberculosis. Potentially anxiogenic.
Product Details
| Alternative Name: | 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1- piperazinyl)-3-quinolinecarboxylic acid |
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| Formula: | C17H18FN3O3 |
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| MW: | 331.3 |
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| CAS: | 85721-33-1 |
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| MI: | 14: 2314 |
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| RTECS: | VB1993800 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to light yellow crystalline powder |
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| Solubility: | Soluble in dilute hydrochloric acid; insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Evaluating the Efficacy of Eravacycline and Omadacycline against Extensively Drug-Resistant Acinetobacter baumannii Patient Isolates: M.S. Deolankar, et al.; Antibiotics
11, 1298 (2022),
Abstract;
Detection of microbial surface contamination and antibiotic resistant Escherichia coli on beef carcasses in Arusha, Tanzania: R. Murutu, et al.; Afr. J. Microbiol. Res.
10, 1148 (2016),
Application(s): Determining antibiotic susceptibility, E. coli isolates,
Full Text
In Vitro Antibacterial Activity of Rhodanine Derivatives against Pathogenic Clinical Isolates: A. AbdelKhalek, et al.; PLoS One
11, e0164227 (2016),
Application(s): In vitro antibacterial activity of rhodanine compounds 1 to 7 against Bacillus anthracis,
Abstract;
Full Text
Anxiogenic potential of ciprofloxacin and norfloxacin in rats: S. Sen, et al.; Singapore Med. J.
48, 1028 (2007),
Abstract;
Full Text
Moxifloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against Mycobacterium tuberculosis: evaluation of in vitro and pharmacodynamic indices that best predict in vivo efficacy: R.K. Shandil, et al.; Antimicrob. Agents Chemother.
51, 576 (2007),
Abstract;
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Ciprofloxacin and norfloxacin, two fluoroquinolone antimicrobials: D.E. Nix & J.M DeVito; Clin. Pharm.
6, 105 (1987),
Abstract;
Mechanisms of action of and resistance to ciprofloxacin: D.C. Hooper, et al.; Am. J. Med.
82, 12 (1987),
Abstract;
Is ciprofloxacin active against clinically important anaerobes?: B. Watt & F.V. Brown; J. Antimicrob. Chemother.
17, 605 (1986),
Abstract;
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