Weak immunosuppressor. Potent inhibitor of tumor promoting phorbol ester TPA/PMA (Prod. No. BML-PE160) in vivo. Potent inhibitor of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro.
Product Details
| Alternative Name: | Val2-cyclosporin, 7-L-Valine-cyclosporin A |
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| Formula: | C63H113N11O12 |
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| MW: | 1216.6 |
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| Source: | Isolated from Fusarium solani. |
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| CAS: | 63775-96-2 |
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| MI: | 14: 2752 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | Colorless to off-white crystalline solid. |
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| Solubility: | Soluble in 100% ethanol, acetone or ethyl acetate; insoluble in water. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro: M. Gschwendt, et al.; BBRC
150, 545 (1988),
Abstract;
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