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Cyclosporin D

TPA/PMA inhibitor
ALX-380-284-M001 1 mg 129.00 USD
ALX-380-284-M005 5 mg 509.00 USD
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Weak immunosuppressor. Potent inhibitor of tumor promoting phorbol ester TPA/PMA (Prod. No. BML-PE160) in vivo. Potent inhibitor of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro.

Product Details

Alternative Name:Val2-cyclosporin, 7-L-Valine-cyclosporin A
Source:Isolated from Fusarium solani.
MI:14: 2752
Purity:≥95% (HPLC)
Appearance:Colorless to off-white crystalline solid.
Solubility:Soluble in 100% ethanol, acetone or ethyl acetate; insoluble in water.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro: M. Gschwendt, et al.; BBRC 150, 545 (1988), Abstract;

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BML-PE160-0005 5 mg 169.00 USD
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