Broad spectrum antibiotic and bacteriostatic. Shows antiprotozoal properties. Potent inhibitor of MMPs (matrix metalloproteinases) in vivo. Inhibits collagen synthesis. Increases and promotes smooth muscle cell adhesion. Inhibits proliferation and migration. Protects microvasculature by inhibiting plasminogen systems.
Product Details
| Alternative Name: | Doxycycline . hydrochloride . hemiethanolate . hemihydrate |
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| Formula: | C46H58Cl2N4O18 |
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| MW: | 1025.87 g/mol |
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| Source: | Semisynthetic from oxytetracycline. |
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| CAS: | 24390-14-5 |
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| MI: | 14: 3440 |
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| RTECS: | QI8925000 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Yellow crystalline solid. |
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| Solubility: | Soluble in water (50mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The CRL4DTL E3 ligase induces degradation of the DNA replication initiation factor TICRR/TRESLIN specifically during S phase: K.A. Wittig, et al.; Nucleic Acids Res.
49, 10507 (2021),
Abstract;
Disulfide bond-disrupting agents activate the tumor necrosis family-related apoptosis-inducing ligand/death receptor 5 pathway: M. Wang, et al.; Cell Death Dis.
5, 153 (2019),
Abstract;
Full Text
Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia: D. Burggraf, et al.; Neurobiol. Dis.
25, 506 (2007),
Abstract;
Doxycycline alters vascular smooth muscle cell adhesion, migration, and reorganization of fibrillar collagen matrices: C. Franco, et al.; Am. J. Pathol.
168, 1697 (2006),
Abstract;
Full Text
Molecular interactions between matrilysin and the matrix metalloproteinase inhibitor doxycycline investigated by deuterium exchange mass spectrometry: R.A. Garcia, et al.; Mol. Pharmacol.
67, 1128 (2005),
Abstract;
Full Text
Doxycycline and tissue repair in rats: S. Lamparter, et al.; J. Lab. Clin. Med.
139, 295 (2002),
Abstract;
Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. Regulation by tumor necrosis factor-alpha and doxycycline: R. Hanemaaijer, et al.; J. Biol. Chem.
272, 31504 (1997),
Abstract;
Full Text
Specificity of the anticollagenase action of tetracyclines: relevance to their anti-inflammatory potential: K. Suomalainen, et al.; Antimicrob. Agents Chemother.
36, 227 (1992),
Abstract;
An efficacy trial of doxycycline chemoprophylaxis against leptospirosis: E.T. Takafuji, et al.; N. Engl. J. Med.
310, 497 (1984),
Abstract;
A compilation of LD50 values in newborn and adult animals: E.I. Goldenthal; Toxicol. Appl. Pharmacol.
18, 185 (1971),
Abstract;
Alpha-6-deoxyoxytetracycline. I. Some biological properties: A.R. English; Proc. Soc. Exp. Biol. Med.
122, 1107 (1966),
Abstract;
