Aminoglycoside antibiotic. Effective against Gram-negative and Gram-positive bacteria.
Product Details
| Formula: | C22H43N5O13 . 2H2SO4 |
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| MW: | 585.6 . 196.2 |
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| Source: | Semisynthetic from kanamycin A (Prod. No. ALX-380-275). |
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| CAS: | 39831-55-5 |
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| MI: | 14: 405 |
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| RTECS: | WK1961200 |
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| Appearance: | White to off-white crystalline powder. |
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| Activity: | Potency is 674-786µg/mg (on dry basis). |
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| Solubility: | Soluble in water (50mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Biological transformation of kanamycin A to amikacin (BBK-8): L.M. Cappelletti & R. Spagnoli; J. Antibiot.
36, 328 (1983),
Abstract;
Ototoxicity and pharmacokinetically determined dosages of amikacin in granulocytopenic cancer patients: F.J. Danhauer, et al.; Clin. Pharm.
1, 539 (1982),
Abstract;
Aminoglycoside antibiotics. VII. Acute toxicity of aminoglycoside antibiotics: K. Fujisawa, et al.; J. Antibiot.
27, 677 (1974),
Abstract;
Pharmacology of amikacin in humans: G.P. Bodey, et al.; Antimicrob. Agents Chemother.
5, 508 (1974),
Abstract;
Comparative in vitro activity of three aminoglycosidic antibiotics: BB-K8, kanamycin, and gentamicin: P.K. Yu & J.A. Washington; Antimicrob. Agents Chemother.
4, 133 (1973),
Abstract;
Comparative pharmacokinetics of BB-K8 and kanamycin in dogs and humans: B.E. Cabana & J.G. Taggart; Antimicrob. Agents Chemother.
3, 478 (1973),
Abstract;
BB-K 8, a new semisynthetic aminoglycoside antibiotic: H. Kawaguchi, et al.; J. Antibiot.
25, 695 (1972),
Abstract;
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