Macrocyclic thiazole antibiotic with potent and selective antibacterial activity. Potent inhibitor of the oncogenic transcription factor forkhead box M1 (FoxM1) that downregulates protein and mRNA levels of FoxM1. Inhibits FoxM1 induced cell growth.
Product Details
| Alternative Name: | Mutabilycin, Sporangiomycin, Antibiotic 6741-21, Mutabillicin |
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| Formula: | C71H81N19O18S5 |
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| MW: | 1648.9 |
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| Source: | Isolated from Streptomyces sp. MST-AS4617. |
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| CAS: | 12656-09-6 |
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| RTECS: | VX0600000 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO or dimethyl formamide; partially soluble in methanol or 100% ethanol; poorly soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The FOXM1/BUB1B signaling pathway is essential for the tumorigenicity and radioresistance of glioblastoma: Q. Ma, et al.; Oncol. Rep.
38, 3367 (2017),
Abstract;
Full Text
Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cells: U.G. Bhat, et al.; PLoS One
4, e5592 (2009),
Abstract;
Future roles for FoxM1 inhibitors in cancer treatments: G.R. Adami & H. Ye; Future Oncol.
3, 1 (2007),
Abstract;
Full Text
Identification of a chemical inhibitor of the oncogenic transcription factor forkhead box M1: S.K. Radhakrishnan, et al.; Cancer Res.
22, 364 (2006),
Abstract;
Full Text
Studies on siomycin. I. Physicochemical properties of siomycins A, B and C: M. Ebata, et al.; J. Antibiot. (Tokyo)
22, 364 (1969),
Abstract;
