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Ristocetin A . sulfate

Antibiotic. Inducer of platelet aggregation
ALX-380-237-M010 10 mg 394.00 USD
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Potent antibacterial antibiotic. Induces platelet aggregation by binding to a factor absent in people suffering from von Willebrand’s disease and is therefore an important diagnostic tool. Chiral selector for the separation of enantiomers by HPLC, TLC and electrophoresis.

Product Details

Alternative Name:Ristocetin . sulfate, Ristomycin III . sulfate, Spontin . sulfate, Riston . sulfate
Formula:C95H110N8O44 . H2SO4
MW:2067.9 . 98.1
Source:Isolated from Amycolatopsis sp. MST-AS5924.
MI:14: 8234
Purity:≥95% (HPLC)
Appearance:Light tan solid.
Solubility:Soluble in water, methanol or DMSO.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

HPLC separation of amino acid enantiomers and small peptides on macrocyclic antibiotic-based chiral stationary phases: a review: I. Ilisz, et al.; J. Sep. Sci. 29, 1305 (2006), (Review), Abstract;
A peptide isolated from alpha B-crystallin is a novel and potent inhibitor of platelet aggregation via dual prevention of PAR-1 and GPIb/V/IX: H. Matsuno, et al.; J. Thromb. Haemost. 1, 2636 (2003), Abstract;
Cooperativity and anti-cooperativity between ligand binding and the dimerization of ristocetin A: asymmetry of a homodimer complex and implications for signal transduction: Y.R. Cho, et al.; Chem. Biol. 3, 207 (1996), Abstract;
Ristocetin--a new tool in the investigation of platelet aggregation: M.A. Howard and B.G. Firkin; Thromb. Diath. Haemorrh. 26, 362 (1971), Abstract;
Ristocetin A and B, two new antibiotics. Isolation and properties: J.E. Philip, et al.; Antibiot. Annu. 1956-1957, 699 (1957),