Potent antibacterial antibiotic. Induces platelet aggregation by binding to a factor absent in people suffering from von Willebrand’s disease and is therefore an important diagnostic tool. Chiral selector for the separation of enantiomers by HPLC, TLC and electrophoresis.
Product Details
| Alternative Name: | Ristocetin . sulfate, Ristomycin III . sulfate, Spontin . sulfate, Riston . sulfate |
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| Formula: | C95H110N8O44 . H2SO4 |
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| MW: | 2067.9 . 98.1 |
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| Source: | Isolated from Amycolatopsis sp. MST-AS5924. |
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| CAS: | 11140-99-1 |
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| MI: | 14: 8234 |
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| RTECS: | VJ8595000 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | Light tan solid. |
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| Solubility: | Soluble in water, methanol or DMSO. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
HPLC separation of amino acid enantiomers and small peptides on macrocyclic antibiotic-based chiral stationary phases: a review: I. Ilisz, et al.; J. Sep. Sci.
29, 1305 (2006), (Review),
Abstract;
A peptide isolated from alpha B-crystallin is a novel and potent inhibitor of platelet aggregation via dual prevention of PAR-1 and GPIb/V/IX: H. Matsuno, et al.; J. Thromb. Haemost.
1, 2636 (2003),
Abstract;
Cooperativity and anti-cooperativity between ligand binding and the dimerization of ristocetin A: asymmetry of a homodimer complex and implications for signal transduction: Y.R. Cho, et al.; Chem. Biol.
3, 207 (1996),
Abstract;
Ristocetin--a new tool in the investigation of platelet aggregation: M.A. Howard and B.G. Firkin; Thromb. Diath. Haemorrh.
26, 362 (1971),
Abstract;
Ristocetin A and B, two new antibiotics. Isolation and properties: J.E. Philip, et al.; Antibiot. Annu. 1956-1957, 699 (1957),
