Antibiotic. Specific and potent inhibitor of NADH-ubiquinone oxidoreductase (complex I) that binds to ubiquinone binding site(s). Inhibits both mitochondrial and bacterial NADH ubiquinone oxidoreductase. Anticancer agent that prevents up-regulation of GRP78, and exhibits cytotoxic activity for etoposide resistant cancer cells under glucose-deprived conditions.
Product Details
| Alternative Name: | Piericidin A1, Shaoguanmycin B, Antibiotic MT 1882-I, Antibiotic SN 198E, Antibiotic IT 143D |
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| Formula: | C25H37NO4 |
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| MW: | 415.6 |
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| Source: | Isolated from Streptomyces sp. MST-AS5364. |
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| CAS: | 2738-64-9 |
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| RTECS: | YD4588000 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | Pale yellow oil. |
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| Solubility: | Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO. Poorly soluble in water. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Rotenone inhibits primary murine myotube formation via Raf-1 and ROCK2: S. Grefte, et al.; Biochim. Biophys. Acta.
1853, 1606 (2015),
Application(s): Cell Culture,
Abstract;
Etoposide-resistant HT-29 human colon carcinoma cells during glucose deprivation are sensitive to piericidin A, a GRP78 down-regulator: J.H. Hwang, et al.; J. Cell. Physiol.
215, 243 (2008),
Abstract;
Evidence for a quinone binding site close to the interface between NUOD and NUOB subunits of Complex I: I. Prieur, et al.; Biochim. Biophys. Acta
1504, 173 (2001),
Abstract;
The 49-kDa subunit of NADH-ubiquinone oxidoreductase (Complex I) is involved in the binding of piericidin and rotenone, two quinone-related inhibitors: E. Darrouzet, et al.; FEBS Lett.
431, 34 (1998),
Abstract;
Two binding sites of inhibitors in NADH: ubiquinone oxidoreductase (complex I). Relationship of one site with the ubiquinone-binding site of bacterial glucose:ubiquinone oxidoreductase: T. Friedrich, et al.; Eur. J. Biochem.
219, 691 (1994),
Abstract;
Piericidin A: a new inhibitor of mitochondrial electron transport: C. Hall, et al.; BBRC
25, 373 (1966),
Abstract;
