Shows potent antitumor activity in vitro and in vivo against several tumor cell lines, including L1210 and P388 leukemia cells. Has antibacterial and antifungal activities. Inhibitor of nuclear export.
Product Details
| Alternative Name: | Hydroxyleptomycin A, Antibiotic CL 1957E, PD 124,895 |
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| Formula: | C32H46O7 |
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| MW: | 542.7 |
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| Source: | Isolated from Streptomyces sp. MST-AS4898. |
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| CAS: | 107140-30-7 |
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| RTECS: | OA0551000 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | Colorless film. |
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| Solubility: | Soluble in 100% ethanol (recommended) or methanol. Unstable in DMSO. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA: B. Wolff, et al.; Chem. Biol.
4, 139 (1997),
Abstract;
The effect of kazusamycin B on the cell cycle and morphology of cultured L1210 cells: K. Takamiya, et al.; J. Antibiot. (Tokyo)
41, 1854 (1988),
Abstract;
Antitumor effect of kazusamycin B on experimental tumors: E. Yoshida, et al.; J. Antibiot. (Tokyo)
40, 1596 (1987),
Abstract;
Kazusamycin B, a novel antitumor antibiotic: K. Funaishi, et al.; J. Antibiot. (Tokyo)
40, 778 (1987),
Abstract;
PD 124,895 and PD 124,966, two new antitumor antibiotics: T.R. Hurley, et al.; J. Antibiot. (Tokyo)
39, 1651 (1986),
Abstract;
