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United States 

Kazusamycin A

Antitumor antibiotic
ALX-380-230-MC01 0.1 mg 555.00 USD
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Shows potent antitumor activity in vitro and in vivo against several tumor cell lines. Has antibacterial and antifungal activities. Inhibitor of nuclear export.

Product Details

Alternative Name:Kazusamycin, Hydroxyleptomycin B, Hydroxyelactocin, Antibiotic CL 1957B, PD 114,721
Source:Isolated from Streptomyces sp. MST-AS4898.
Purity:≥95% (HPLC)
Appearance:Colorless film.
Solubility:Soluble in 100% ethanol (recommended) or methanol. Unstable in DMSO.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA: B. Wolff, et al.; Chem. Biol. 4, 139 (1997), Abstract;
In vivo and in vitro anticancer activity of the structurally novel and highly potent antibiotic CI-940 and its hydroxy analog (PD 114,721): B.J. Roberts, et al.; Cancer Chemother. Pharmacol. 16, 95 (1986), Abstract;
Antitumor activity of a new antibiotic, kazusamycin: K. Komiyama, et al.; J. Antibiot. (Tokyo) 38, 224 (1985), Abstract;
Novel antitumor antibiotics, CI-940 (PD 114,720) and PD 114,721. Taxonomy, fermentation and biological activity: J.B. Tunac, et al.; J. Antibiot. (Tokyo) 38, 460 (1985), Abstract;
A new antitumor antibiotic, kazusamycin: I. Umezawa, et al.; J. Antibiot. (Tokyo) 37, 706 (1984), Abstract;