Shows potent antitumor activity in vitro and in vivo against several tumor cell lines. Has antibacterial and antifungal activities. Inhibitor of nuclear export.
Product Details
| Alternative Name: | Kazusamycin, Hydroxyleptomycin B, Hydroxyelactocin, Antibiotic CL 1957B, PD 114,721 |
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| Formula: | C33H48O7 |
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| MW: | 556.7 |
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| Source: | Isolated from Streptomyces sp. MST-AS4898. |
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| CAS: | 92090-94-3 |
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| RTECS: | OA0550000 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | Colorless film. |
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| Solubility: | Soluble in 100% ethanol (recommended) or methanol. Unstable in DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA: B. Wolff, et al.; Chem. Biol.
4, 139 (1997),
Abstract;
In vivo and in vitro anticancer activity of the structurally novel and highly potent antibiotic CI-940 and its hydroxy analog (PD 114,721): B.J. Roberts, et al.; Cancer Chemother. Pharmacol.
16, 95 (1986),
Abstract;
Antitumor activity of a new antibiotic, kazusamycin: K. Komiyama, et al.; J. Antibiot. (Tokyo)
38, 224 (1985),
Abstract;
Novel antitumor antibiotics, CI-940 (PD 114,720) and PD 114,721. Taxonomy, fermentation and biological activity: J.B. Tunac, et al.; J. Antibiot. (Tokyo)
38, 460 (1985),
Abstract;
A new antitumor antibiotic, kazusamycin: I. Umezawa, et al.; J. Antibiot. (Tokyo)
37, 706 (1984),
Abstract;
