Isomer of apoptolidin (Prod. No. ALX-380-207). In water an equilibrium mixture of apoptolidin:isoapoptolidin (~1.5:1) is formed within hours. Less active F0F1-ATPase inhibitor (IC50=17µM) than apoptolidin (IC50=0.7µM).
Product Details
| Formula: | C58H96O21 |
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| MW: | 1129.4 |
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| Source: | Isolated from Amycolatopsis sp. MST-AS5912. |
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| CAS: | 476647-30-0 |
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| Purity: | ≥90% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Isoapoptolidin: structure and activity of the ring-expanded isomer of apoptolidin: P.A. Wender, et al.; Org. Lett.
4, 3819 (2002),
Abstract;
Toward a stable apoptolidin derivative: identification of isoapoptolidin and selective deglycosylation of apoptolidin: J.D. Pennington, et al.; Org. Lett.
4, 3823 (2002),
Abstract;
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