Macrolide antibiotic. Potent inhibitor of mitochondrial ATP synthase complex, acting on the F0 membrane sector. Shows antifungal activity.
Product Details
| Alternative Name: | Aabomycin A2 |
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| Formula: | C40H66O10 |
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| MW: | 707 |
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| Source: | Isolated from Streptomyces sp. MST-117594. |
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| CAS: | 33538-72-6 |
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| MI: | 14: 9947 |
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| Formulation: | Lyophilized. |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Potassium selective and venturicidin sensitive conductances of Fo purified from bovine heart mitochondria, reconstituted in planar lipid bilayers: H. Miedema, et al.; BBRC
203, 1005 (1994),
Abstract;
Studies on the mechanism of oxidative phosphorylation. ATP synthesis by submitochondrial particles inhibited at F0 by venturicidin and organotin compounds: A. Matsuno-Yagi and Y. Hatefi; J. Biol. Chem.
268, 6158 (1993),
Abstract;
Full Text
Amino acid substitutions in mitochondrial ATP synthase subunit 9 of Saccharomyces cerevisiae leading to venturicidin or ossamycin resistance: M. Galanis, et al.; FEBS Lett.
249, 333 (1989),
Abstract;
Inhibition of Escherichia coli H+-ATPase by venturicidin, oligomycin and ossamycin: D.S. Perlin, et al.; Biochim. Biophys. Acta
807, 238 (1985),
Abstract;
Venturicidin: a new antifungal antibiotic of potential use in agriculture: A. Rhodes, et al.; Nature
192, 952 (1961),
Abstract;
