Antibiotic. Selective and competitive cholinergic antagonist that distinguishes subtypes of cholinergic receptors. Anti-helmintic.
Product Details
| Alternative Name: | VM 29919 |
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| Formula: | C28H35N3O5 |
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| MW: | 493.6 |
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| Source: | Isolated from Penicillium simplicissimum MST-FP116A. |
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| CAS: | 77392-58-6 |
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| RTECS: | RV0545000 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Evaluation of broad-spectrum anthelmintic activity in a novel assay against Haemonchus contortus, Trichostrongylus colubriformis and T. sigmodontis in the gerbil Meriones unguiculatus: D.A. Ostlind, et al.; J. Helminthol.
80, 393 (2006),
Abstract;
Anthelmintic paraherquamides are cholinergic antagonists in gastrointestinal nematodes and mammals: E.W. Zinser, et al.; J. Vet. Pharmacol. Ther.
25, 241 (2002),
Abstract;
Paraherquamide and 2-deoxy-paraherquamide distinguish cholinergic receptor subtypes in Ascaris muscle: A.P. Robertson, et al.; J. Pharmacol. Exp. Ther.
302, 853 (2002),
Abstract;
Full Text
Acute toxicity of paraherquamide and its potential as an anthelmintic: W.L. Shoop, et al.; Am. J. Vet. Res.
53, 2032 (1992),
Abstract;
Novel antinematodal and antiparasitic agents from Penicillium charlesii. I. Fermentation, isolation and biological activity: J.G. Ondeyka, et al.; J. Antibiot. (Tokyo)
43, 1375 (1990),
Abstract;
