Macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase. Shows antibacterial, antifungal, insecticidal and antihelmintic activity. Potential antiosteoporotic agent in treating bone lytic diseases.
Product Details
| Alternative Name: | L-681,110A1 |
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| Formula: | C39H60O12 |
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| MW: | 720.9 |
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| Source: | Isolated from Streptomyces sp. MST-AS5338. |
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| CAS: | 88979-61-7 |
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| Purity: | ≥95% (HPLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | White to light-brown solid. |
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| Solubility: | Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO. |
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| Shipping: | Ambient Temperature |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Use/Stability: | May undergo transformation to methyl ketal on long term storage in methanol. We recommend to use fresh solutions. Stable for at least 1 year after receipt when stored at -20°C. |
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| Handling: | After reconstitution protect from light at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Structure and function of V-ATPases in osteoclasts: potential therapeutic targets for the treatment of osteolysis: J. Xu, et al.; Histol. Histopathol.
222, 443 (2007),
Abstract;
Bafilolides, potent inhibitors of the motility and development of the free-living stages of parasitic nematodes: E. Lacey, et al.; Int. J. Parasitol.
25, 349 (1995),
Abstract;
Purification of vacuolar ATPase with bafilomycin C1 affinity chromatography: T.J. Rautiala, et al.; BBRC
194, 50 (1993),
Abstract;
Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity: G. Werner, et al.; J. Antibiot. (Tokyo)
37, 110 (1984),
Abstract;
