Antitumor antibiotic. Displays nanomolar cytotoxicity to murine P388 leukemia cells. Analog of leptomycin B (Prod. No. ALX-380-100), an inhibitor of nuclear protein export.
Product Details
| Alternative Name: | 5-Demethylleptomycin A, KR 2827A |
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| Formula: | C31H44O6 |
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| MW: | 512.7 |
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| Source: | Isolated from Streptomyces sp. MST-AS5546. |
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| CAS: | 111278-01-4 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | Pale yellow film. |
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| Solubility: | Soluble in 100% ethanol (recommended) or methanol. Unstable in DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Anguinomycins C and D, new antitumor antibiotics with selective cytotoxicity against transformed cells: Y. Hayakawa, et al.; J. Antibiot. (Tokyo)
48, 954 (1995),
Abstract;
New antitumor antibiotics, anguinomycins A and B: Y. Hayakawa, et al.; J. Antibiot. (Tokyo)
40, 1349 (1987),
Abstract;
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