Antitumor antibiotic. Inhibits cell cycle at the G(2)/M phase and induces apoptosis.
Product Details
| Alternative Name: | NSC357683, XK 213 |
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| Formula: | C10H9NO5 |
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| MW: | 223.2 |
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| Source: | Isolated from Streptomyces sp. |
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| CAS: | 79127-35-8 |
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| RTECS: | JW5313000 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in dimethyl formamide, methanol or water. |
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| Shipping: | Shipped on Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. |
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| Handling: | After reconstitution protect from light at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Echinosporins as new cell cycle inhibitors and apoptosis inducers from marine-derived Streptomyces albogriseolus: C.B. Cui, et al.; Fitoterapia
78, 238 (2007),
Abstract;
Biosynthesis of the antibiotic echinosporin by a novel branch of the shikimate pathway: A. Dubeler; Eur. J. Org. Chem. 2002, 983 (2002),
Applications of an asymmetric [2 + 2]-photocycloaddition. Total synthesis of (-)-echinosporin. Construction of an advanced 11-deoxyprostaglandin intermediate: A. B. Smith; JACS 114, 2567 (1992),
Approaches to the total synthesis of the antitumor antibiotic echinosporin: M. A. Kinsella; J. Org. Chem. 55, 105 (1990),
Antitumor activity of echinosporin: M. Morimoto and R. Imai; J. Antibiot.
38, 490 (1985),
Abstract;
A new antibiotic echinosporin (XK-213) - producing organism, isolation and characterization: T. Sato, et al.; J. Antibiot.
35, 266 (1982),
Abstract;
