Tetracycline derivative with antimicrobial activity. Inhibitor of angiogenesis, apoptosis and poly(ADP-ribose) polymerase-1 (PARP-1).
MMP inhibitor.
Anti-inflammatory and neuroprotective.
Product Details
| Alternative Name: | Dynacin, Klinomycin, Minocin, Vectrin |
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| Formula: | C23H27N3O7 . HCl |
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| MW: | 457.5 . 36.5 |
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| Source: | Semisynthetic. |
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| CAS: | 13614-98-7 |
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| MI: | 14: 6202 |
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| RTECS: | QI7630500 |
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| Purity: | ≥98% (UHPLC) |
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| Appearance: | Yellow crystalline solid. |
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| Solubility: | Soluble in water (50mg/ml, warm) or DMSO (7mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Matrix metalloproteinase inhibitors attenuate neuroinflammation following focal cerebral ischemia in mice: C.H. Park, et al.; Korean J. Physiol. Pharmacol.
15, 115 (2011),
Abstract;
Comparison of doxycycline and minocycline in the inhibition of VEGF-induced smooth muscle cell migration: J.S. Yao, et al.; Neurochem. Int.
50, 524 (2007),
Abstract;
Minocycline, a second-generation tetracycline, as a neuroprotective agent in an animal model of schizophrenia: Y. Levkovitz, et al.; Brain Res.
1154, 154 (2007),
Abstract;
Multiple neuroprotective mechanisms of minocycline in autoimmune CNS inflammation: K. Maier, et al.; Neurobiol. Dis.
25, 514 (2007),
Abstract;
Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations: C.C. Alano, et al.; PNAS
103, 9685 (2006),
Abstract;
Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy: J.K. Krady, et al.; Diabetes
54, 1559 (2005),
Abstract;
Minocycline up-regulates BCL-2 levels in mitochondria and attenuates male germ cell apoptosis: M. Castanares, et al.; BBRC
337, 663 (2005),
Abstract;
Minocycline exerts multiple inhibitory effects on vascular endothelial growth factor-induced smooth muscle cell migration: the role of ERK1/2, PI3K, and matrix metalloproteinases: J.S. Yao, et al.; Circ. Res.
95, 364 (2004),
Abstract;
Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria: J. Wang, et al.; J. Biol. Chem.
279, 19948 (2004),
Abstract;
Local delivery of minocycline and systemic BCNU have synergistic activity in the treatment of intracranial glioma: J.L. Frazier, et al.; J. Neurooncol.
64, 203 (2003),
Abstract;
