Antibiotic. Exhibits similar activity as concanamycin A (Prod. No. ALX-380-034) and C (Prod. No. ALX-380-099). Specific inhibitor of vacuolar-type H+-ATPase. Suppresses bone resorption in vitro. Inhibits proliferation of mouse splenic lymphocytes. Shows antifungal and larvicidal properties.
Product Specification
Formula: | C45H73NO14 |
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MW: | 852.1 |
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Source: | Isolated from Streptomyces sp. |
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CAS: | 81552-33-2 |
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Purity: | ≥95% (HPLC) |
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Identity: | Determined by 1H-NMR. |
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Appearance: | White to off-white solid. |
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Solubility: | Soluble in chloroform, methanol, acetonitrile or DMSO. Insoluble in water. |
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Shipping: | Ambient |
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Short Term Storage: | +4°C |
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Long Term Storage: | -20°C |
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Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. |
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Handling: | After reconstitution protect from light at -20°C. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
In vivo rapid reduction of alloantigen-activated CD8+ mature cytotoxic T cells by inhibitors of acidification of intracellular organelles, prodigiosin 25-C and concanamycin B: M. H. Lee, et al.; Immunology
99, 243 (2000),
Abstract;
Concanamycin B, a vacuolar H(+)-ATPase specific inhibitor suppresses bone resorption in vitro: J.T. Woo, et al.; Biol. Pharm. Bull.
19, 297 (1996),
Abstract;
Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells: F.J. Sharom, et al.; Biochem. J.
308 (Pt2), 381 (1995),
Abstract;
Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules on the cell surface: K. Ito, et al.; J. Antibiot.
48, 488 (1995),
Abstract;
Involvement of the vacuolar H(+)-ATPases in the secretory pathway of HepG2 cells: M. Yilla, et al.; J. Biol. Chem.
268, 19092 (1993),
Abstract;
Isolation and characterization of concanamycins A, B and C: H. Kinashi, et al.; J. Antibiot. (Tokyo)
37, 1333 (1984),
Abstract;
Structures of concanamycins B and C: H. Kinashi, et al.; J. Antibiot.
35, 1618 (1982),
Abstract;
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