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Concanamycin B

V-ATPase inhibitor
ALX-380-098-C100 100 µg 773.00 USD
ALX-380-098-C500 500 µg 2,646.00 USD
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Antibiotic. Exhibits similar activity as concanamycin A (Prod. No. ALX-380-034) and C (Prod. No. ALX-380-099). Specific inhibitor of vacuolar-type H+-ATPase. Suppresses bone resorption in vitro. Inhibits proliferation of mouse splenic lymphocytes. Shows antifungal and larvicidal properties.

Product Details

Source:Isolated from Streptomyces sp.
Purity:≥95% (HPLC)
Identity:Determined by 1H-NMR.
Appearance:White to off-white solid.
Solubility:Soluble in chloroform, methanol, acetonitrile or DMSO. Insoluble in water.
Short Term Storage:+4°C
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
Handling:After reconstitution protect from light at -20°C.
Regulatory Status:RUO - Research Use Only
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Product Literature References

In vivo rapid reduction of alloantigen-activated CD8+ mature cytotoxic T cells by inhibitors of acidification of intracellular organelles, prodigiosin 25-C and concanamycin B: M. H. Lee, et al.; Immunology 99, 243 (2000), Abstract;
Concanamycin B, a vacuolar H(+)-ATPase specific inhibitor suppresses bone resorption in vitro: J.T. Woo, et al.; Biol. Pharm. Bull. 19, 297 (1996), Abstract;
Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells: F.J. Sharom, et al.; Biochem. J. 308 (Pt2), 381 (1995), Abstract;
Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules on the cell surface: K. Ito, et al.; J. Antibiot. 48, 488 (1995), Abstract;
Involvement of the vacuolar H(+)-ATPases in the secretory pathway of HepG2 cells: M. Yilla, et al.; J. Biol. Chem. 268, 19092 (1993), Abstract;
Isolation and characterization of concanamycins A, B and C: H. Kinashi, et al.; J. Antibiot. (Tokyo) 37, 1333 (1984), Abstract;
Structures of concanamycins B and C: H. Kinashi, et al.; J. Antibiot. 35, 1618 (1982), Abstract;

Related Products

Concanamycin A 

H+ ATPase inhibitor
80890-47-7, Isolated from Streptomyces sp., ≥98% (HPLC) | Print as PDF
ALX-380-034-C025 25 µg 273.00 USD
ALX-380-034-C100 100 µg 819.00 USD
ALX-380-034-M001 1 mg 2,875.00 USD
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Concanamycin C 

V-ATPase inhibitor
81552-34-3, Isolated from Streptomyces sp., ≥96% (HPLC) | Print as PDF
ALX-380-099-C500 500 µg 2,792.00 USD
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