Antitumor antibiotic which inhibits topoisomerase II. Induces single-strand scission in DNA in the presence of reducing agents.
Product Specification
| Alternative Name: | Lambdamycin |
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| Formula: | C32H32O14 |
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| MW: | 640.6 |
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| Source: | Isolated from Streptomyces chartreusis. |
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| CAS: | 6377-18-0 |
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| MI: | 14: 2045 |
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| RTECS: | FL7350000 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in acetone; insoluble in water. |
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| Shipping: | Ambient |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | +4°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at +4°C. |
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| Handling: | After reconstitution protect from light at -20°C. |
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Product Literature References
Chartreusin, elsamicin A and related anti-cancer antibiotics: J. Portugal; Curr. Med. Chem. Anticancer Agents
3, 411 (2003), Review,
Abstract;
Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II: A. Lorico & B.H. Long; Eur. J. Cancer
14, 1985 (1993),
Abstract;
Chartreusin, a glycosidic antitumour antibiotic from Streptomyces: J.A. Beisler; Prog. Med. Chem.
19, 247 (1982), (Review),
Abstract;
Chartreusin, a New Antibiotic Produced by Streptomyces chartreusis, a New Species: B. E. Leach, et al.; J. Am. Chem. Soc. 75, 4011 (1953),
