Antibiotic. Disrupts the actin microfilament cytoskeleton and inhibits the cytoplasmic dividing of a cell. Has been found to be ten times less toxic in mice than cytochalasin D (Prod. No.
BML-T109) but with essentially the same biological effectiveness against cells in culture.
Product Specification
| Formula: | C30H37NO6 |
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| MW: | 507.6 |
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| Source: | Isolated from Metarhizium anisopliae. |
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| CAS: | 22144-76-9 |
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| MI: | 14: 2790 |
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| RTECS: | HA5300500 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in DMSO, 100% ethanol or dichloromethane. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Alteration in cell morphology triggers transforming growth factor-beta 1, collagenase, and tissue inhibitor of metalloproteinases-I expression in normal and hypertrophic scar fibroblasts: M. Varedi, et al.; J. Invest. Dermatol.
104, 118 (1995),
Abstract;
Actin assembly activity of cytochalasins and cytochalasin analogs assayed using fluorescence photobleaching recovery: E.A. Walling, et al.; Arch. Biochem. Biophys.
264, 321 (1988),
Abstract;
