Antibiotic. Inhibitor of HIV-1 reverse transcriptase (RT). Inhibits human telomerase. Cytostatically active against different tumor cell lines.
Product Details
| Formula: | C27H20O12 |
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| MW: | 536.5 |
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| Source: | Isolated from Streptomyces sp. |
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| CAS: | 27267-70-5 |
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| Purity: | ≥99% |
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| Solubility: | Soluble in chloroform. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Scaffold Hopping of α-Rubromycin Enables Direct Access to FDA-Approved Cromoglicic Acid as a SARS-CoV-2 M Pro Inhibitor: H. A. Alhadrami, et al.; Pharmaceuticals
14, 541 (2021),
Abstract;
Inhibition of human telomerase by rubromycins: implication of spiroketal system of the compounds as an active moiety: T. Ueno, et al.; Biochemistry
39, 5995 (2000),
Abstract;
Structural and Biosynthetic Investigations of the Rubromycins: C. Puder, et al.; Eur. J. Org. Chem. 2000, 729 (2000),
Inhibition of human immunodeficiency virus-1 reverse transcriptase activity by rubromycins: competitive interaction at the template.primer site: M.E. Goldman, et al.; Mol. Pharmacol.
38, 20 (1990),
Abstract;
Rubromycins. 3. The constitution of alpha-rubromycin, beta-rubromycin, gamma-rubromycin, and gamma-iso-rubromycin: H. Brockmann & A. Zeeck; Chem. Ber.
103, 1709 (1970),
Abstract;
Rubromycin II: H. Brockmann, et al.; Chem. Ber.
102, 126 (1969),
Abstract;
The structure of rubromycin: H. Brockmann, et al.; THL
30, 3525 (1966), (Article in German),
Abstract;
