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Endothelin receptor antagonist
ALX-380-066-C500 500 µg 764.00 USD
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Potent endothelin receptor antagonist. Anti-osteoporotic compound. Shows remarkable antibacterial and cytotoxic activity. Mediates its cytotoxic effects, at least in part, through proteasome inhibition.

Product Details

Alternative Name:(-)-TAN 2162
Source:Isolated from Streptomyces violaceoruber.
Purity:≥98% (HPLC)
Identity:Determined by 1H-NMR.
Appearance:Yellow powder.
Solubility:Slightly soluble in DMSO or methanol.
Short Term Storage:+4°C
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
Handling:After reconstitution protect from light at -20°C.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Evidence for the mode of action of the highly cytotoxic Streptomyces polyketide kendomycin: Y.A. Elnakady, et al.; Chembiochem. 8, 1261 (2007), Abstract;
Structure and biosynthesis of kendomycin, a carboxylic ansa-compound from Streptomyces: A.Zeeck & H.B. Bode; J. Chem. Soc. Perkin Trans. 323 (2000),