Potent endothelin receptor antagonist. Anti-osteoporotic compound. Shows remarkable antibacterial and cytotoxic activity. Mediates its cytotoxic effects, at least in part, through proteasome inhibition.
Product Specification
| Alternative Name: | (-)-TAN 2162 |
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| Formula: | C29H42O6 |
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| MW: | 486.6 |
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| Source: | Isolated from Streptomyces violaceoruber. |
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| CAS: | 183202-73-5 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | Yellow powder. |
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| Solubility: | Slightly soluble in DMSO or methanol. |
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| Shipping: | Ambient |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. |
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| Handling: | After reconstitution protect from light at -20°C. |
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Product Literature References
Evidence for the mode of action of the highly cytotoxic Streptomyces polyketide kendomycin: Y.A. Elnakady, et al.; Chembiochem.
8, 1261 (2007),
Abstract;
Structure and biosynthesis of kendomycin, a carboxylic ansa-compound from Streptomyces: A.Zeeck & H.B. Bode; J. Chem. Soc. Perkin Trans. 323 (2000),
